Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

Huntington's disease (HD) is an autosomal neurodegenerative disease that is characterized
by an excessive number of CAG trinucleotide repeats within the huntingtin gene (HTT). HD …

Abstract Insulin-like growth factor-1 (IGF-1), a pleiotropic polypeptide, plays an essential role
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …

The expanded HTT CAG repeat causing Huntington's disease (HD) exhibits somatic
expansion proposed to drive the rate of disease onset by eliciting a pathological process …

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by expansion
of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin (HTT) gene …

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG
trinucleotide repeat expansion in the huntingtin gene. Previously, we showed strong …

Neurodegenerative diseases (NDDs) are disorders characterized by progressive
deterioration of brain structure and function. Selective neuronal populations are affected …

There are currently no effective pharmacological agents available to stop or prevent the
progression of Huntington's disease (HD), a rare hereditary neurodegenerative disorder. In …

Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …

Abstract 5΄-Vinylphosphonate modification of siRNAs protects them from phosphatases, and
improves silencing activity. Here, we show that 5΄-vinylphosphonate confers novel …