Drosophila models of cardiac disease
N Piazza, RJ Wessells - Progress in molecular biology and translational …, 2011 - Elsevier
The fruit fly Drosophila melanogaster has emerged as a useful model for cardiac diseases,
both developmental abnormalities and adult functional impairment. Using the tools of both …
both developmental abnormalities and adult functional impairment. Using the tools of both …
Methods to assess Drosophila heart development, function and aging
In recent years the Drosophila heart has become an established model for many different
aspects of human cardiac disease. This model has allowed identification of disease-causing …
aspects of human cardiac disease. This model has allowed identification of disease-causing …
High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila
RT Birse, J Choi, K Reardon, J Rodriguez, S Graham… - Cell metabolism, 2010 - cell.com
Summary High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and
cardiovascular disease, but the underlying genetic mechanisms are poorly understood …
cardiovascular disease, but the underlying genetic mechanisms are poorly understood …
A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy
J Na, LP Musselman, J Pendse, TJ Baranski… - PLoS …, 2013 - journals.plos.org
Diets high in carbohydrates have long been linked to progressive heart dysfunction, yet the
mechanisms by which chronic high sugar leads to heart failure remain poorly understood …
mechanisms by which chronic high sugar leads to heart failure remain poorly understood …
A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts
M Fink, C Callol-Massot, A Chu, P Ruiz-Lozano… - …, 2009 - Taylor & Francis
The genetic basis of heart development is remarkably conserved from Drosophila to
mammals, and insights from flies have greatly informed our understanding of vertebrate …
mammals, and insights from flies have greatly informed our understanding of vertebrate …
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function
GG Neely, K Kuba, A Cammarato, K Isobe, S Amann… - Cell, 2010 - cell.com
Heart diseases are the most common causes of morbidity and death in humans. Using
cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061 evolutionarily …
cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061 evolutionarily …
α-Cardiac myosin heavy chain (MYH6) mutations affecting myofibril formation are associated with congenital heart defects
JT Granados-Riveron, TK Ghosh, M Pope… - Human molecular …, 2010 - academic.oup.com
Congenital heart defects (CHD) are collectively the most common form of congenital
malformation. Studies of human cases and animal models have revealed that mutations in …
malformation. Studies of human cases and animal models have revealed that mutations in …
Semi-automated optical heartbeat analysis of small hearts
K Ocorr, M Fink, A Cammarato, SI Bernstein… - JoVE (Journal of …, 2009 - jove.com
Semi-automated Optical Heartbeat Analysis of Small Hearts - JoVE JoVE JoVE Faculty
Resource Center Research Behavior Biochemistry Biology Bioengineering Cancer …
Resource Center Research Behavior Biochemistry Biology Bioengineering Cancer …
A Mighty Small Heart: The Cardiac Proteome of Adult Drosophila melanogaster
Drosophila melanogaster is emerging as a powerful model system for the study of cardiac
disease. Establishing peptide and protein maps of the Drosophila heart is central to …
disease. Establishing peptide and protein maps of the Drosophila heart is central to …
Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype
O Taghli‐Lamallem, T Akasaka, G Hogg, U Nudel… - Aging cell, 2008 - Wiley Online Library
A number of studies have been conducted recently on the model organism Drosophila to
determine the function of genes involved in human disease, including those implicated in …
determine the function of genes involved in human disease, including those implicated in …