The fruit fly Drosophila melanogaster has emerged as a useful model for cardiac diseases,
both developmental abnormalities and adult functional impairment. Using the tools of both …

In recent years the Drosophila heart has become an established model for many different
aspects of human cardiac disease. This model has allowed identification of disease-causing …

Summary High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and
cardiovascular disease, but the underlying genetic mechanisms are poorly understood …

Diets high in carbohydrates have long been linked to progressive heart dysfunction, yet the
mechanisms by which chronic high sugar leads to heart failure remain poorly understood …

The genetic basis of heart development is remarkably conserved from Drosophila to
mammals, and insights from flies have greatly informed our understanding of vertebrate …

Heart diseases are the most common causes of morbidity and death in humans. Using
cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061 evolutionarily …

Congenital heart defects (CHD) are collectively the most common form of congenital
malformation. Studies of human cases and animal models have revealed that mutations in …

Semi-automated Optical Heartbeat Analysis of Small Hearts - JoVE JoVE JoVE Faculty
Resource Center Research Behavior Biochemistry Biology Bioengineering Cancer …

Drosophila melanogaster is emerging as a powerful model system for the study of cardiac
disease. Establishing peptide and protein maps of the Drosophila heart is central to …

A number of studies have been conducted recently on the model organism Drosophila to
determine the function of genes involved in human disease, including those implicated in …