The main function of the lung is to perform gas exchange while maintaining lung
homeostasis despite environmental pathogenic and non-pathogenic elements contained in …

Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …

Macrophages derived from human induced pluripotent stem cells (iPSCs) have the potential
to enable the development of cell-based therapies for numerous disease conditions. We …

Alveolar macrophages (AMs) are lung tissue-resident macrophages that can be expanded
in culture, but it is unknown to what extent culture affects their in vivo identity. Here we show …

The natural history of COPD is complex, and the disease is best understood as a syndrome
resulting from numerous interacting factors throughout the life cycle with smoking being the …

The increasing number of severe infections with multi-drug-resistant pathogens worldwide
highlights the need for alternative treatment options. Given the pivotal role of phagocytes …

Macrophages are immune cells with important roles in tissue homeostasis, inflammation and
pathologies. Hence, macrophage populations represent promising targets for modern …

A renewable source of human monocytes and macrophages would be a valuable alternative
to primary cells from peripheral blood (PB) in biomedical research. We developed an …

Aims The alternatively activated macrophages have shown a cardioprotective effect in heart
failure. However, the effect of M2 adoptive transfer in non-ischemic heart failure is unknown …

The respiratory system acts as both the primary site of gas exchange and an important
sensor and barrier to the external environment. The increase in incidences of respiratory …