Once a transplanted organ is exposed to the defense mechanisms of a recipient, its survival
is mainly determined by the strength of the recipient's anti-donor immune response. Despite …

The pathogenesis of diabetic nephropathy remains poorly defined, and animal models that
represent the human disease have been lacking. It was demonstrated recently that the …

Midkine (MK) is a multifunctional heparin-binding protein and promotes migration of
neutrophils, macrophages, and neurons. In the normal mouse kidney, MK is expressed in …

Tissue factor is a transmembrane protein that activates the extrinsic coagulation pathway by
binding factor VII. Endothelial cells, being in contact with circulating blood, do not normally …

Accommodation refers to the acquired resistance of a graft to immune-mediated injury. It is
typically observed after antibodies that would cause rejection of a graft are removed from a …

E-selectin and its ligands are essential for extravasation of leukocytes in inflammation. Here,
we report that basigin (Bsg)/CD147 is a ligand for E-selectin that promotes renal …

The renin-angiotensin system plays a pivotal role in regulating blood pressure and is
involved in the pathogenesis of kidney disorders and other diseases. Here, we report that …

Background. The most difficult barrier to organ transplantation is humoral rejection, a
condition initiated by binding of antibodies to blood vessels in the graft. Fortunately, humoral …

Vascular endothelial growth factor A (VEGF-A) can play both beneficial and deleterious
roles in renal diseases, where its specific function might be determined by nitric oxide …

B cell tolerance has been generally understood to be an acquired property of the immune
system that governs antibody specificity in ways that avoid auto‐toxicity. As useful as this …