[HTML][HTML] The scaffold-forming steps of plant alkaloid biosynthesis

BR Lichman - Natural Product Reports, 2021 - pubs.rsc.org
Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …

[HTML][HTML] Applications of synthetic biology in medical and pharmaceutical fields

X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

[HTML][HTML] A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids

ME Pyne, K Kevvai, PS Grewal, L Narcross… - Nature …, 2020 - nature.com
The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive
natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ …

Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products

B Gao, B Yang, X Feng, C Li - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2015 to 2020 Nitrogen heterocyclic natural products (NHNPs) are primary or
secondary metabolites containing nitrogen heterocyclic (N-heterocyclic) skeletons. Due to …

Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update

A Singh, IM Menéndez-Perdomo, PJ Facchini - Phytochemistry Reviews, 2019 - Springer
For nearly eight millennia, opium poppy (Papaver somniferum) has been bred and cultivated
for therapeutic purposes. The medicinal properties of the plant are conferred by specialized …

Biosynthesis and synthetic biology of psychoactive natural products

CS Jamieson, J Misa, Y Tang… - Chemical Society Reviews, 2021 - pubs.rsc.org
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

[HTML][HTML] Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation

N Ozber, SC Carr, JS Morris, S Liang… - Nature …, 2022 - nature.com
Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids
including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers …

[HTML][HTML] Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation

D Mancinotti, KM Frick, F Geu-Flores - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Quinolizidine alkaloids (QAs) are a class of alkaloids that accumulate
in a variety of leguminous plants and have applications in the agricultural, pharmaceutical …

Biological functions of major latex-like proteins in plants

K Fujita, H Inui - Plant Science, 2021 - Elsevier
Major latex-like proteins (MLPs) have been identified in dicots and monocots. They are
members of the birch pollen allergen Bet v 1 family as well as pathogenesis-related proteins …

Discovery, Structure, and Mechanism of the (R, S)-Norcoclaurine Synthase for the Chiral Synthesis of Benzylisoquinoline Alkaloids

L Zhang, S Zhang, L Liao, H Tang, W Wang, F Yin… - ACS …, 2023 - ACS Publications
Benzylisoquinoline alkaloids (BIAs) are key plant metabolites that offer significant
pharmacological benefits. While most naturally isolated BIAs are identified as (S) …