[HTML][HTML] The scaffold-forming steps of plant alkaloid biosynthesis
BR Lichman - Natural Product Reports, 2021 - pubs.rsc.org
Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …
privileged position in both modern and traditional medicines. In recent years, there have …
[HTML][HTML] Applications of synthetic biology in medical and pharmaceutical fields
X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …
bioproperties. During the past decades, progresses have been made to build delicate …
[HTML][HTML] A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids
The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive
natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ …
natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ …
Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products
B Gao, B Yang, X Feng, C Li - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2015 to 2020 Nitrogen heterocyclic natural products (NHNPs) are primary or
secondary metabolites containing nitrogen heterocyclic (N-heterocyclic) skeletons. Due to …
secondary metabolites containing nitrogen heterocyclic (N-heterocyclic) skeletons. Due to …
Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update
A Singh, IM Menéndez-Perdomo, PJ Facchini - Phytochemistry Reviews, 2019 - Springer
For nearly eight millennia, opium poppy (Papaver somniferum) has been bred and cultivated
for therapeutic purposes. The medicinal properties of the plant are conferred by specialized …
for therapeutic purposes. The medicinal properties of the plant are conferred by specialized …
Biosynthesis and synthetic biology of psychoactive natural products
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …
structural complexity displayed by such molecules confers diverse biological activities of …
[HTML][HTML] Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation
Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids
including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers …
including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers …
[HTML][HTML] Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation
D Mancinotti, KM Frick, F Geu-Flores - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Quinolizidine alkaloids (QAs) are a class of alkaloids that accumulate
in a variety of leguminous plants and have applications in the agricultural, pharmaceutical …
in a variety of leguminous plants and have applications in the agricultural, pharmaceutical …
Biological functions of major latex-like proteins in plants
Major latex-like proteins (MLPs) have been identified in dicots and monocots. They are
members of the birch pollen allergen Bet v 1 family as well as pathogenesis-related proteins …
members of the birch pollen allergen Bet v 1 family as well as pathogenesis-related proteins …
Discovery, Structure, and Mechanism of the (R, S)-Norcoclaurine Synthase for the Chiral Synthesis of Benzylisoquinoline Alkaloids
L Zhang, S Zhang, L Liao, H Tang, W Wang, F Yin… - ACS …, 2023 - ACS Publications
Benzylisoquinoline alkaloids (BIAs) are key plant metabolites that offer significant
pharmacological benefits. While most naturally isolated BIAs are identified as (S) …
pharmacological benefits. While most naturally isolated BIAs are identified as (S) …