Cancer is a leading cause of mortality and morbidity globally. Many prominent cancer-
associated molecules have been identified over the recent years which include EGFR …

Detection of apoptotic cell death in cells and tissues has become of paramount importance
in many fields of modern biology, including studies of embryonic development, degenerative …

Analysis of autoinflammatory and immunodeficiency disorders elucidates human immunity
and fosters the development of targeted therapies. Oligoadenylate synthetase 1 is a type I …

Publisher Summary This chapter describes an assay that helps bridge the gap between
measurement of CD8+ T-cell cytolytic activity and the identity of the effector CD8+ T cells …

7-Aminoactinomycin D (7-AAD) is a DNA dye that distinguishes viable, apoptotic, and late
apoptotic/dead cells in flow cytometry. Several staining protocols using 7-AAD have been …

Cell-mediated cytotoxicity is a crucial mechanism involved in several fundamental
immunological processes such as protection against intracellular pathogens or termination …

The reliability of eight distinct methods (Giemsa staining, trypan blue exclusion, acridine
orange/ethidium bromide (AO/EB) double staining for fluorescence microscopy and flow …

The in vivo differentiation of CD4 T cells from naive to memory cells was followed after their
adoptive transfer together with syngeneic dendritic cells into MHC mismatched adoptive …

PURPOSE: Flavopiridol is the first cyclin-dependent kinase inhibitor to enter clinical trials.
Activity in gastric cancer xenografts and in a patient with gastric cancer on the phase I trial …

Dietary indole-3-carbinol (I3C) has clinical benefits for both cervical cancer and laryngeal
papillomatosis, and causes apoptosis of breast cancer cells in vitro. We asked whether I3C …