Dark classics in chemical neuroscience: 3, 4-methylenedioxymethamphetamine

LE Dunlap, AM Andrews, DE Olson - ACS chemical neuroscience, 2018 - ACS Publications
Better known as “ecstasy”, 3, 4-methylenedioxymethamphetamine (MDMA) is a small
molecule that has played a prominent role in defining the ethos of today's teenagers and …

A proposed mechanism for the MDMA-mediated extinction of traumatic memories in PTSD patients treated with MDMA-assisted therapy

RJ Sottile, T Vida - Frontiers in psychiatry, 2022 - frontiersin.org
Post-traumatic stress disorder (PTSD) is a devastating psychiatric disorder afflicting millions
of people around the world. Characterized by severe anxiety, intrusive thoughts, pervasive …

Distinct neural mechanisms for the prosocial and rewarding properties of MDMA

BD Heifets, JS Salgado, MD Taylor… - Science translational …, 2019 - science.org
The extensively abused recreational drug (±) 3, 4-methylenedioxymethamphetamine
(MDMA) has shown promise as an adjunct to psychotherapy for treatment-resistant …

Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD

JJ Walsh, P Llorach, DF Cardozo Pinto… - …, 2021 - nature.com
Autism spectrum disorder (ASD) is a common set of heterogeneous neurodevelopmental
disorders resulting from a variety of genetic and environmental risk factors. A core feature of …

Using conditioned place preference to identify relapse prevention medications

TC Napier, AA Herrold, H De Wit - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
Stimuli, including contexts, which predict the availability or onset of a drug effect, can acquire
conditioned incentive motivational properties. These conditioned properties endure after …

The neurochemistry of social reward during development: What have we learned from rodent models?

A Manduca, E Carbone, S Schiavi… - Journal of …, 2021 - Wiley Online Library
Social rewards are fundamental to survival and overall health. Several studies suggest that
adequate social stimuli during early life are critical for developing appropriate …

Dopamine D1 and D3 receptor polypharmacology as a potential treatment approach for substance use disorder

E Galaj, S Ewing, R Ranaldi - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
In the search for efficacious pharmacotherapies to treat cocaine addiction much attention
has been given to agents targeting dopamine D1 or D3 receptors because of the …

Dose and time-dependent selective neurotoxicity induced by mephedrone in mice

J Martinez-Clemente, R Lopez-Arnau, S Abad, D Pubill… - Plos one, 2014 - journals.plos.org
Mephedrone is a drug of abuse marketed as 'bath salts". There are discrepancies
concerning its long-term effects. We have investigated the neurotoxicity of mephedrone in …

Mephedrone and MDMA: a comparative review

J Mead, A Parrott - Brain research, 2020 - Elsevier
Mephedrone and MDMA are both constituents of party drugs, with mephedrone being
relatively new compared to MDMA. This review compares current knowledge regarding the …

Neuronal changes and oxidative stress in adolescent rats after repeated exposure to mephedrone

R López-Arnau, J Martínez-Clemente, T Rodrigo… - Toxicology and applied …, 2015 - Elsevier
Mephedrone is a new designer drug of abuse. We have investigated the neurochemical/
enzymatic changes after mephedrone administration to adolescent rats (3× 25 mg/kg, sc in a …