Xenobiotic metabolism and transport in Caenorhabditis elegans

JH Hartman, SJ Widmayer… - Journal of Toxicology …, 2021 - Taylor & Francis
Caenorhabditis elegans has emerged as a major model in biomedical and environmental
toxicology. Numerous papers on toxicology and pharmacology in C. elegans have been …

Polymeric zinc-doped nanoparticles for high performance in restorative dentistry

M Toledano, M Vallecillo-Rivas, FS Aguilera… - Journal of dentistry, 2021 - Elsevier
Objectives The aim was to state the different applications and the effectiveness of polymeric
zinc-doped nanoparticles to achieve dentin remineralization. Data, sources and study …

[HTML][HTML] Juggling cadmium detoxification and zinc homeostasis: a division of labour between the two C. elegans metallothioneins

YJ Essig, OI Leszczyszyn, N Almutairi… - Chemosphere, 2024 - Elsevier
The chemical properties of toxic cadmium and essential zinc are very similar, and organisms
require intricate mechanisms that drive selective handling of metals. Previously regarded as …

Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor

BJ Earley, C Cubillas, K Warnhoff… - Proceedings of the …, 2021 - National Acad Sciences
Cadmium is an environmental pollutant and significant health hazard that is similar to the
physiological metal zinc. In Caenorhabditis elegans, high zinc homeostasis is regulated by …

[HTML][HTML] Cadmium stress dictates central carbon flux and alters membrane composition in Streptococcus pneumoniae

SL Neville, BA Eijkelkamp, A Lothian, JC Paton… - Communications …, 2020 - nature.com
Metal ion homeostasis is essential for all forms of life. However, the breadth of intracellular
impacts that arise upon dysregulation of metal ion homeostasis remain to be elucidated …

The molecular basis of Acinetobacter baumannii cadmium toxicity and resistance

SF Alquethamy, FG Adams, R Maharjan… - Applied and …, 2021 - Am Soc Microbiol
Acinetobacter species are ubiquitous Gram-negative bacteria that can be found in water, in
soil, and as commensals of the human skin. The successful inhabitation of Acinetobacter …

[HTML][HTML] Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans

KS Evans, S Zdraljevic, L Stevens, K Collins… - PLoS …, 2020 - journals.plos.org
Zinc is an essential trace element that acts as a co-factor for many enzymes and
transcription factors required for cellular growth and development. Altering intracellular zinc …

[HTML][HTML] The effect of metal mixture composition on toxicity to C. elegans at individual and population levels

S Moyson, RM Town, K Vissenberg, R Blust - PLoS One, 2019 - journals.plos.org
The toxicity of zinc (Zn), copper (Cu), and cadmium (Cd) to the nematode Caenorhabditis
elegans was characterised under single metal and mixture scenarios at different …

[HTML][HTML] Toxicity of Per-and Polyfluoroalkyl Substances to Nematodes

T Ma, X Pan, T Wang, X Li, Y Luo - Toxics, 2023 - mdpi.com
Per-and polyfluoroalkyl substances (PFASs) are a class of compounds that persist in the
environment globally. Besides being transported to the soil and sediments, which act as …

[HTML][HTML] A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

EM Chapman, B Lant, Y Ohashi, B Yu… - Nature …, 2019 - nature.com
Apoptotic death of cells damaged by genotoxic stress requires regulatory input from
surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian …