Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …

Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …

The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

INTRODUCTION Diversity in the sequence of the human genome, arising from
recombinations and mutations, is fundamental to human evolution and human diversity …

Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …

Current models propose that boundaries of mammalian topologically associating domains
(TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by …

Mammalian embryonic stem cells (ESCs) and sperm exhibit unusual chromatin packaging
that plays important roles in cellular function. Here, we extend a recently developed …

Conventional methods for single-cell genome sequencing are limited with respect to
uniformity and throughput. Here, we describe sci-L3, a single-cell sequencing method that …

Background DNA methylation at promoters is largely correlated with inhibition of gene
expression. However, the role of DNA methylation at enhancers is not fully understood …