Open thoracic surgical implantation of cardiac pacemakers in rats

RT Yin, SW Chen, K Benjamin Lee, YS Choi, J Koo… - Nature protocols, 2023 - nature.com
Genetic engineering and implantable bioelectronics have transformed investigations of
cardiovascular physiology and disease. However, the two approaches have been difficult to …

Research progress of myocardial fibrosis and atrial fibrillation

G Li, J Yang, D Zhang, X Wang, J Han… - Frontiers in …, 2022 - frontiersin.org
With the aging population and the increasing incidence of basic illnesses such as
hypertension and diabetes (DM), the incidence of atrial fibrillation (AF) has increased …

Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females

AE Marquardt, JW VanRyzin, RW Fuquen… - Frontiers in Behavioral …, 2023 - frontiersin.org
Social play is a dynamic and rewarding behavior abundantly expressed by most mammals
during the juvenile period. While its exact function is debated, various rodent studies on the …

VDAC1 in the diseased myocardium and the effect of VDAC1-interacting compound on atrial fibrosis induced by hyperaldosteronism

H Klapper-Goldstein, A Verma, S Elyagon, R Gillis… - Scientific reports, 2020 - nature.com
The voltage-dependent anion channel 1 (VDAC1) is a key player in mitochondrial function.
VDAC1 serves as a gatekeeper mediating the fluxes of ions, nucleotides, and other …

Is PTSD-phenotype associated with HPA-axis sensitivity? Feedback inhibition and other modulating factors of glucocorticoid signaling dynamics

D Danan, D Todder, J Zohar, H Cohen - International journal of molecular …, 2021 - mdpi.com
Previously, we found that basal corticosterone pulsatility significantly impacts the
vulnerability for developing post-traumatic stress disorder (PTSD). Rats that exhibited PTSD …

Ion channels as a therapeutic target for renal fibrosis

P Yan, B Ke, X Fang - Frontiers in Physiology, 2022 - frontiersin.org
Renal ion channel transport and electrolyte disturbances play an important role in the
process of functional impairment and fibrosis in the kidney. It is well known that there are …

An objective tool for quantifying atrial fibrillation substrate in rats

M Murninkas, R Gillis, S Elyagon… - American Journal …, 2023 - journals.physiology.org
The utility of rodents for research related to atrial fibrillation (AF) is growing exponentially.
However, the obtained arrhythmic waveforms are often mixed with ventricular signals and …

More obvious association between short-term ambient nitrogen dioxide and atrial fibrillation outpatient visits in cool seasons: A hospital-based study in northwestern …

CB Zhou, YG Hu, YN Fan, N Wu, CY Yao, XL Liu… - Environmental …, 2022 - Elsevier
Atrial fibrillation (AF) is the most common sustained heart rhythm disorder associated with
high mortality and morbidity. Limited studies have been conducted to assess the relationship …

A new implantable tool for repeated assessment of supraventricular electrophysiology and atrial fibrillation susceptibility in freely moving rats

M Murninkas, R Gillis, DI Lee… - American Journal …, 2021 - journals.physiology.org
The complex pathophysiology of atrial fibrillation (AF) is governed by multiple risk factors in
ways that are still elusive. Basic electrophysiological properties, including atrial effective …

Cannabinoid Receptor Agonist Inhibits Atrial Electrical Remodeling in a Tachypaced Ex Vivo Rat Model

DI Lee, M Murninkas, S Elyagon, Y Etzion… - Frontiers in …, 2021 - frontiersin.org
Introduction: Atrial fibrillation (AF) leads to rate-dependent atrial changes collectively defined
as atrial remodelling (AR). Shortening of the atrial effective refractory period (AERP) and …