The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Abstract Treatment-resistant schizophrenia (TRS), the persistence of positive symptoms
despite≥ 2 trials of adequate dose and duration of antipsychotic medication with …

The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia seeks to reduce these substantial psychosocial and public health …

Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third
of patients do not show adequate improvement in positive symptoms with non-clozapine …

Treatment-resistant schizophrenia (TRS) represents a major clinical challenge. The broad
definition of TRS requires nonresponse to at least 2 sequential antipsychotic trials of …

The availability of long-acting injectable (LAI) antipsychotics for the treatment of
schizophrenia provides clinicians with options that deliver continuous drug exposure and …

Importance Long-acting injectable antipsychotics (LAIs) can potentially reduce
hospitalization risk by enhancing medication adherence but are rarely considered for early …

Background Most individuals with schizophrenia-spectrum disorders have relapses, which
increase the risk of morbidity and mortality. Because non-adherence to antipsychotic …

Importance The doses of antipsychotic drugs needed for relapse prevention in
schizophrenia is a debated issue. Objective To examine dose-response findings in a meta …

This review describes the Hierarchical Taxonomy of Psychopathology (HiTOP) model of
psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis …