Langerhans cell histiocytosis: NACHO update on progress, chaos, and opportunity on the path to rational cures

K Bielamowicz, P Dimitrion, O Abla, S Bomken… - Cancer, 2024 - Wiley Online Library
Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by
lesions with CD1a‐positive/Langerin (CD207)‐positive histiocytes and inflammatory infiltrate …

Phase 2 study using low dose cytarabine for adult patients with newly diagnosed Langerhans cell histiocytosis

L Chang, M Lang, H Lin, H Cai, MH Duan, DB Zhou… - Leukemia, 2024 - nature.com
Langerhans cell histiocytosis (LCH) lacks a standardized first-line therapy. This single-
center, phase 2 prospective study (NCT04121819) enrolled 61 newly diagnosed adult LCH …

Approach to the Patient: From Endocrinopathy to the Diagnosis of a Histiocytic Disorder

P Makras, D Erickson, CJ Davidge-Pitts… - The Journal of …, 2024 - academic.oup.com
Endocrinopathies are frequently the initial presentation of histiocytic neoplasms, which are
rare hematologic disorders affecting multiple organ systems. Langerhans cell histiocytosis …

Clinical characteristics, molecular aberrations, treatments, and outcomes of malignant histiocytosis

GJ Ruan, S Zanwar, A Ravindran… - American journal of …, 2024 - Wiley Online Library
Malignant histiocytosis (MH) is an extremely rare neoplasm of the macrophage–dendritic
cell lineage. We report the clinical characteristics, molecular aberrations, treatments, and …

Long Term Follow-up of Methotrexate and Cytarabine in Adult Patients with Langerhans Cell Histiocytosis

H Lin, X Cao, L Chang, M Lang, ZZ Liu, M Duan… - Blood, 2024 - Elsevier
Background: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm characterized
by the proliferation and accumulation of mononuclear phagocytes across diverse tissues …

[HTML][HTML] Multisystemic recurrent Langerhans cell histiocytosis misdiagnosed with chronic inflammation at the first diagnosis: A case report

ZR Zhang, F Chen, HJ Chen - World Journal of Radiology, 2024 - pmc.ncbi.nlm.nih.gov
BACKGROUND Langerhans cell histiocytosis (LCH) is characterized by diabetes insipidus
and is an uncommon occurrence. Pathological biopsies still have a certain degree of …

Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review

J Zhao, Y Li, Y Zhang, X Mei, W Liu, Y Li - Journal of Hematopathology, 2024 - Springer
Langerhans cell histiocytosis (LCH) of the stomach is rare. Moreover, it is usually found in
pediatric patients with systemic diseases and may be associated with a poor prognosis …

A Case of Spontaneous Regression of Adult Multi-system Langerhans Cell Histiocytosis Presenting as Liver Tumor Rupture

S Oshima, S Inano, G Honjo, S Tabata, M Fujimoto… - Internal …, 2024 - jstage.jst.go.jp
Adult multisystem Langerhans cell histiocytosis (MS-LCH) is rare and has a poor prognosis.
A 67-year-old man with MS-LCH presented with a hepatic tumor rupture and multiple …

[HTML][HTML] Langerhans Cell Histiocytosis Treatment (PDQ®): Treatment-Health Professional Information [NCI]

L Home, C Care, CC Home - kids.networkofcare.org
Histiocytic diseases in children and adults are caused by an abnormal accumulation of cells
of the mononuclear phagocytic system. This summary discusses only Langerhans cell …

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