Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases,
minimally containing a well conserved catalytic subunit, the activity of which is highly …

Sphingolipids are important components of eukaryotic cells, many of which function as
bioactive signaling molecules. Of these, ceramide is a central metabolite and plays key roles …

Recent years have witnessed significant advances in the understanding of the role of
ceramide in apoptosis. This review summarizes these recent findings and discusses insights …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

Phosphorylation and dephosphorylation of a protein often serve as an “on-and-off” switch in
the regulation of cellular activities. Recent studies demonstrate the involvement of protein …

A reduced capacity for insulin to elicit increases in glucose uptake and metabolism in target
tissues such as skeletal muscle is a common feature of obesity and diabetes. The …

Cyclin G2, together with cyclin G1 and cyclin I, defines a novel cyclin family expressed in
terminally differentiated tissues including brain and muscle. Cyclin G2 expression is up …

Accumulation of ceramide has been reported in stress-and receptor-induced apoptosis in
the nervous system. However, its role in apoptosis signaling remains elusive. We describe …

Proper formation of protein phosphatase 2A (PP2A) holoenzymes is essential for the fitness
of all eukaryotic cells. Carboxyl methylation of the PP2A catalytic subunit plays a critical role …

Sphingolipids have emerged as key regulatory molecules in cancer cell survival and death.
Although important roles of sphingolipids in breast cancer progression have been reported …