The formation of organophosphate molecules by prebiotic processes relies on
nonenzymatic synthesis. Given the centrality of phosphorylated biomolecules in metabolic …

Phosphorus is an element critical to the formation of several biomolecules, including nucleic
acids, the energy transfer molecule ATP, and phospholipids. It hence lies at the heart of …

Environmental phosphate concentrations are typically much lower (~ 10− 6 M) than needed
for prebiotic phosphorylation of nucleosides, critical for the origin of life. Here, we tested …

The incorporation of orthophosphate from scarce geochemical sources into the organic
compounds essential for life under mild conditions is a fundamental challenge for prebiotic …

Context. Although solid-state pathways are expected to dominate the formation mechanisms
of many complex organic molecules (COMs), very few COMs have been securely identified …

The phosphorylation of nucleosides and their polymerization are crucial issues concerning
the origin of life. The question of how these plausible chemical processes took place in the …

The emergence and evolution of prebiotic biomolecules on the early Earth remain a
question that is considered crucial to understanding the chemistry of the origin of life …

Organophosphates were likely an important class of prebiotic molecules. However, their
presence on the early Earth is strongly debated because the low availability of phosphate …

Life's origins have always been a scientific puzzle. Understanding the production of
biomolecules is crucial for understanding the evolution of life on Earth. Numerous studies on …

The availability of nucleotides on the early Earth is of great significance for the origin of a self-
replicating system capable of undergoing evolution. We hereby report the successful …