Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

S Zeng, X Liu, YS Kafuti, H Kim, J Wang… - Chemical Society …, 2023 - pubs.rsc.org
Since their inception, rhodamine dyes have been extensively applied in biotechnology as
fluorescent markers or for the detection of biomolecules owing to their good optical physical …

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

H Li, H Kim, F Xu, J Han, Q Yao, J Wang, K Pu… - Chemical Society …, 2022 - pubs.rsc.org
The discovery of a near-infrared (NIR, 650–900 nm) fluorescent chromophore hemicyanine
dye with high structural tailorability is of great significance in the field of detection …

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

H Li, H Kim, J Han, VN Nguyen, X Peng, J Yoon - Aggregate, 2021 - Wiley Online Library
Activity‐based approaches for designing AIEgens possess prominent advantages including
high selectivity, sensitivity, and signal‐to‐noise ratio, and they have received more attention …

Emerging near infrared fluorophore: Dicyanoisophorone-based small-molecule fluorescent probes with large stokes shifts for bioimaging

L Dai, Q Zhang, Q Ma, W Lin - Coordination Chemistry Reviews, 2023 - Elsevier
Dicyanoisophorone (DCI) has been used extensively as a quality acceptor for designing
chemical sensors targeting different analytes, and developing a series of well-established …

Recent progress on photodynamic therapy and photothermal therapy

H Kim, M Yang, N Kwon, M Cho, J Han… - Bulletin of the …, 2023 - Wiley Online Library
Noninvasive treatments for terminal cancer patients constitute a new trend in tumor
treatment. Therefore, phototherapy, including photodynamic therapy (PDT) and …

Activation of apoptosis by rationally constructing NIR amphiphilic AIEgens: surmounting the shackle of mitochondrial membrane potential for amplified tumor ablation

H Li, Y Lu, J Chung, J Han, H Kim, Q Yao, G Kim… - Chemical …, 2021 - pubs.rsc.org
In recent years, the use of aggregation-induced emission luminogens (AIEgens) for
biological imaging and phototherapy has become an area of intense research. However …

Precise gliomas therapy: hypoxia-activated prodrugs sensitized by nano-photosensitizers

H Zhang, C Shi, F Han, M Li, H Ma, R Sui, S Long… - Biomaterials, 2022 - Elsevier
Hypoxia is one of the prominent features of solid tumors. Hypoxia activated prodrugs
(HAPs), selectively killing hypoxic cells, possess the potential to transform hypoxia from a …

Synchronized activating therapeutic nano-agent: Enhancement and tracing for hypoxia-induced chemotherapy

H Zhang, C Shi, F Han, L Cai, H Ma, S Long, W Sun… - Biomaterials, 2023 - Elsevier
Prodrug is a potential regime to overcome serious adverse events and off-target effects of
chemotherapy agents. Among various prodrug activators, hypoxia stands out owing to the …

A PROTAC Augmenter for Photo‐Driven Pyroptosis in Breast Cancer

D Huang, Y Zou, H Huang, J Yin, S Long… - Advanced …, 2024 - Wiley Online Library
Proteolysis targeting chimera (PROTAC) has recently emerged as a promising strategy for
inducing post‐translational knockdown of target proteins in disease treatment. The …

Activated supramolecular nano-agents: From diagnosis to imaging-guided tumor treatment

J Han, H Li, J Yoon - Nano Today, 2022 - Elsevier
Supramolecular well-ordered nanomaterials have been successfully amplifying the
efficiency of phototherapy in early diagnosis and timely remedies through noncovalent …