Cognitive impact of COVID-19: looking beyond the short term

S Miners, PG Kehoe, S Love - Alzheimer's research & therapy, 2020 - Springer
COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

SARS-CoV-2 infectivity and neurological targets in the brain

WJ Lukiw, A Pogue, JM Hill - Cellular and molecular neurobiology, 2022 - Springer
The gateway for invasion by the novel severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) into human host cells is via the angiotensin-converting enzyme 2 (ACE2) …

The COVID-19 pandemic and Alzheimer's disease: mutual risks and mechanisms

F Chen, Y Chen, Y Wang, Q Ke, L Cui - Translational neurodegeneration, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially …

MAP/ERK signaling in developing cognitive and emotional function and its effect on pathological and neurodegenerative processes

H Albert-Gascó, F Ros-Bernal… - International journal of …, 2020 - mdpi.com
The signaling pathway of the microtubule-associated protein kinase or extracellular
regulated kinase (MAPK/ERK) is a common mechanism of extracellular information …

MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer's Disease

YS Chun, MY Kim, SY Lee, MJ Kim, TJ Hong… - Molecular …, 2022 - nature.com
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder, which is
characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular …

SARS-CoV-2: is there neuroinvasion?

C McQuaid, M Brady, R Deane - Fluids and Barriers of the CNS, 2021 - Springer
Abstract Background SARS-CoV-2, a coronavirus (CoV), is known to cause acute respiratory
distress syndrome, and a number of non-respiratory complications, particularly in older male …

ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway

F Chen, Y Chen, Q Ke, Y Wang, Z Gong… - Journal of Translational …, 2023 - Springer
Background Recent numerous epidemiology and clinical association studies reported that
ApoE polymorphism might be associated with the risk and severity of coronavirus disease …

Blood-brain barrier crossing renin-angiotensin drugs and cognition in the elderly: a meta-analysis

JK Ho, F Moriarty, JJ Manly, EB Larson, DA Evans… - …, 2021 - Am Heart Assoc
Hypertension is an established risk factor for cognitive decline and dementia in older adults,
highlighting the potential importance of antihypertensive treatments in prevention efforts …

Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future

F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …