Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent
high-grade gliomas. However, the efficacy of TMZ is often limited by the development of …

Background Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied
and prescribed antidepressants, while their exact molecular and cellular mechanism are yet …

Triple negative breast cancer (TNBC) is an aggressive type of breast cancer characterized
by the absence of defined molecular targets, including estrogen receptor (ER), progesterone …

Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a
mean life expectancy of less than 15 months. This is due in part to the high resistance to …

Glioma is the most common malignant intracranial tumor and exhibits diffuse metastasis and
a high recurrence rate. The invasive property of glioma results from cell detachment. Anoikis …

Background/purpose Triple-negative breast cancer (TNBC) is the most aggressive and
chemoresistant subtype of breast cancer. Therefore, new molecular targets and treatments …

Persisters are a subpopulation of normal bacterial cells that show tolerance to conventional
antibiotics. Persister cells are responsible for recalcitrant chronic infections and new …

Purpose: Zoledronic acid is being increasingly recognized for its antitumor properties, but
the underlying functions are not well understood. In this study, we hypothesized that …

Background Triple-negative breast cancers (TNBCs) are initially responsive to
chemotherapy, but most recurrent TNBCs develop resistance. Autophagy is believed to play …