Diet, serving as a vital source of nutrients, exerts a profound influence on human health and
disease progression. Recently, dietary interventions have emerged as promising adjunctive …

Nutrition profoundly influences the risk for many age‐related diseases. Whether nutrition
influences human aging biology directly is less clear. Studies in different animal species …

The mechanisms that confer cognitive resilience to Alzheimer's Disease (AD) are not fully
understood. Here, we describe a neural circuit mechanism underlying this resilience in a …

Background: Atherosclerosis (AS) is still the major cause of cardiovascular disease (CVD)
as well as stroke. Endothelial metabolic disorder has been found to be activated and then …

CD4+ T cells play a notable role in immune protection at different stages of life. During
aging, the interaction between the body's internal and external environment and CD4+ T …

Down syndrome (DS), caused by trisomy 21 (T21), results in immune and metabolic
dysregulation. People with DS experience co-occurring conditions at higher rates than the …

To explain why individuals exposed to identical stressors experience divergent clinical
outcomes, we determine how molecular encoding of stress modifies genetic risk for brain …

Simple Summary This review explores the intricate connections between diet, neurological
disorders, and metabolic health, highlighting their significant impact on physiological …

The choroid plexus (CP) plays a key role in remotely controlling brain function in health,
aging, and disease. Here, we report that CP epithelial cells express the brain-specific …

Vascular endothelial injury initiates atherosclerosis (AS) progression. N-Acetylneuraminic
acid (Neu5Ac) metabolic disorder was found to intensify endothelial mitochondrial damage …