Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Individuals with Down syndrome show cellular and clinical features of dysregulated aging of
the immune system, including a shift from naïve to memory T cells and increased incidence …

Intrachromosomal amplification of chromosome 21 defines a subtype of high-risk childhood
acute lymphoblastic leukemia (iAMP21-ALL) characterized by copy number changes and …

Objectives: Cannabis is a known teratogen. Data availability addressing both major
congenital anomalies and cannabis use allowed us to explore their geospatial relationships …

Regulation of global transcription output is important for normal development and disease,
but little is known about the mechanisms involved. DNA topoisomerase I (TOP1) is an …

Structural and numerical alterations of chromosome 21 are extremely common in
hematological malignancies. While the functional impact of chimeric transcripts from fused …

Chromatin organization is a highly orchestrated process that influences gene expression, in
part by modulating access of regulatory factors to DNA and nucleosomes. Here, we report …

SARS-CoV-2 infection has spread uncontrollably worldwide while it remains unknown how
vulnerable populations, such as Down syndrome (DS) individuals are affected by the COVID …

Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of
developing acute leukemia compared to the overall population. Many studies investigating …