[HTML][HTML] E3 ubiquitin ligases: styles, structures and functions

Q Yang, J Zhao, D Chen, Y Wang - Molecular biomedicine, 2021 - Springer
E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination
cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2 …

Inhibitors of the ATPase p97/VCP: From basic research to clinical applications

S Kilgas, K Ramadan - Cell Chemical Biology, 2023 - cell.com
Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …

[HTML][HTML] Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping

Z Zhang, B Sie, A Chang, Y Leng, C Nardone… - Molecular cell, 2023 - cell.com
The ubiquitin-proteasome system plays a critical role in biology by regulating protein
degradation. Despite their importance, precise recognition specificity is known for a few of …

[HTML][HTML] EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion

A Marzio, E Kurz, JM Sahni, G Di Feo, J Puccini… - Cell, 2022 - cell.com
Non-small cell lung cancers (NSCLCs) harboring KEAP1 mutations are often resistant to
immunotherapy. Here, we show that KEAP1 targets EMSY for ubiquitin-mediated …

[HTML][HTML] Inhibition of UBA6 by inosine augments tumour immunogenicity and responses

L Zhang, L Jiang, L Yu, Q Li, X Tian, J He… - Nature …, 2022 - nature.com
Anti-cancer immunity and response to immune therapy is influenced by the metabolic states
of the tumours. Immune checkpoint blockade therapy (ICB) is known to involve metabolic …

Towards artificial intelligence to multi-omics characterization of tumor heterogeneity in esophageal cancer

J Li, L Li, P You, Y Wei, B Xu - Seminars in Cancer Biology, 2023 - Elsevier
Esophageal cancer is a unique and complex heterogeneous malignancy, with substantial
tumor heterogeneity: at the cellular levels, tumors are composed of tumor and stromal …

[HTML][HTML] Signaling pathways regulated by UBR box-containing E3 ligases

JG Kim, HC Shin, T Seo, L Nawale, G Han… - International journal of …, 2021 - mdpi.com
UBR box E3 ligases, also called N-recognins, are integral components of the N-degron
pathway. Representative N-recognins include UBR1, UBR2, UBR4, and UBR5, and they …

[HTML][HTML] Conserved degronome features governing quality control associated proteolysis

B Mashahreh, S Armony, KE Johansson… - Nature …, 2022 - nature.com
The eukaryotic proteome undergoes constant surveillance by quality control systems that
either sequester, refold, or eliminate aberrant proteins by ubiquitin-dependent mechanisms …

[HTML][HTML] Ubiquitin ligases in cancer: functions and clinical potentials

S Duan, M Pagano - Cell chemical biology, 2021 - cell.com
Ubiquitylation, a highly regulated post-translational modification, controls many cellular
pathways that are critical to cell homeostasis. Ubiquitin ligases recruit substrates and …

[HTML][HTML] Systematic prediction of degrons and E3 ubiquitin ligase binding via deep learning

C Hou, Y Li, M Wang, H Wu, T Li - BMC biology, 2022 - Springer
Background Degrons are short linear motifs, bound by E3 ubiquitin ligase to target protein
substrates to be degraded by the ubiquitin-proteasome system. Mutations leading to …