Genetics of Alzheimer's disease in the African American population
Black/African American (AA) individuals have a higher risk of Alzheimer's disease (AD) than
White non-Hispanic persons of European ancestry (EUR) for reasons that may include …
White non-Hispanic persons of European ancestry (EUR) for reasons that may include …
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist
Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …
Endo-lysosomal dysfunction in neurodegenerative diseases: Opinion on current progress and future direction in the use of exosomes as biomarkers
M Herman, GW Randall, JL Spiegel… - … of the Royal …, 2024 - royalsocietypublishing.org
Over the past two decades, increased research has highlighted the connection between
endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an …
endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an …
[HTML][HTML] Conserved and divergent gene regulatory programs of the mammalian neocortex
Divergence of cis-regulatory elements drives species-specific traits, but how this manifests in
the evolution of the neocortex at the molecular and cellular level remains unclear. Here we …
the evolution of the neocortex at the molecular and cellular level remains unclear. Here we …
Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals
Iron plays a fundamental role in multiple brain disorders. However, the genetic
underpinnings of brain iron and its implications for these disorders are still lacking. Here, we …
underpinnings of brain iron and its implications for these disorders are still lacking. Here, we …
The Rotterdam Study. Design update and major findings between 2020 and 2024
MA Ikram, BCT Kieboom, WP Brouwer… - European Journal of …, 2024 - Springer
Abstract The Rotterdam Study is a population-based cohort study, started in 1990 in the
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …
Identification of candidate biomarkers of Alzheimer's disease via multiplex cerebrospinal fluid and serum proteomics
P Liu, L Li, F He, F Meng, X Liu, Y Su, X Su… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most prevalent form of dementia among elderly people
worldwide. Cerebrospinal fluid (CSF) is the optimal fluid source for AD biomarkers, while …
worldwide. Cerebrospinal fluid (CSF) is the optimal fluid source for AD biomarkers, while …
Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer
SORL1, the gene encoding the large multidomain SORLA protein, has emerged as only the
fourth gene that when mutated can by itself cause Alzheimer's disease (AD), and as a gene …
fourth gene that when mutated can by itself cause Alzheimer's disease (AD), and as a gene …
On the causal role of retromer-dependent endosomal recycling in Alzheimer's disease
On the causal role of retromer-dependent endosomal recycling in Alzheimer’s disease | Nature
Cell Biology Skip to main content Thank you for visiting nature.com. You are using a browser …
Cell Biology Skip to main content Thank you for visiting nature.com. You are using a browser …
Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies
Cerebrospinal fluid (CSF) is a clear, transparent fluid derived from blood plasma that
protects the brain and spinal cord against mechanical shock, provides buoyancy, clears …
protects the brain and spinal cord against mechanical shock, provides buoyancy, clears …