[PDF][PDF] Osteoarthritis pathophysiology: therapeutic target discovery may require a multifaceted approach

TL Vincent, T Alliston, M Kapoor, RF Loeser… - Clinics in geriatric …, 2022 - Elsevier
Molecular understanding of osteoarthritis (OA) has greatly increased over the past 15 years
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic '∼ …

Regional disparities, age-related changes and sex-related differences in knee osteoarthritis

J Di, J Bai, J Zhang, J Chen, Y Hao, J Bai… - BMC Musculoskeletal …, 2024 - Springer
Background The objective of the study is to analyse the regions, age and sex differences in
the incidence of knee osteoarthritis (KOA). Methods Data were extracted from the global …

Geniculate artery embolization: role in knee hemarthrosis and osteoarthritis

DB Heller, AE Beggin, AH Lam, MP Kohi, MB Heller - Radiographics, 2022 - pubs.rsna.org
Roughly 37% of Americans 60 years of age and older experience chronic pain due to
osteoarthritis (OA) of the knee. After conservative treatment (pharmacologic, physical …

Quality indicators for osteoarthritis pain management in the primary care setting

E Rizk, S Tajchman, E Fink, DK Aryal, T Iso… - BMC Musculoskeletal …, 2023 - Springer
Background Development of valid and feasible quality indicators (QIs) is needed to track
quality initiatives for osteoarthritis pain management in primary care settings. Methods …

Advances in Interventional Radiology Technology for the Treatment of Knee Osteoarthritis

D Parhar, R Dhatt, SH Liu, A Slater, L Liu… - Orthopedic …, 2024 - orthopedic.theclinics.com
Osteoarthritis (OA) is a leading cause of disability in the United States, where over 30 million
people are affected. 1 Specifically, OA of the knee is one of the 5 leading causes of disability …

Opioid use among Medicare beneficiaries with knee osteoarthritis: prevalence and correlates of chronic use

E Losina, S Song, GP Bensen… - Arthritis care & research, 2023 - Wiley Online Library
Objective To determine the prevalence of chronic and occasional opioid use and identify risk
factors of opioid use among persons with knee osteoarthritis (OA). Methods We used the …

CRISPR-mediated Sox9 activation and RelA inhibition enhance cell therapy for osteoarthritis

L Zhao, Y Lai, H Jiao, J Li, K Lu, J Huang - Molecular Therapy, 2024 - cell.com
Osteoarthritis (OA) is a painful and debilitating disease affecting over 500 million people
worldwide. Intraarticular injection of mesenchymal stromal cells (MSCs) shows promise for …

Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis

GP Bensen, AC Rogers, VP Leifer, RR Edwards… - Osteoarthritis and …, 2023 - Elsevier
Objective Gabapentin can treat neuropathic pain syndromes and has increasingly been
prescribed to treat nociplastic pain. Some patients with knee osteoarthritis (OA) suffer from …

Anti-depressant medication use is a risk factor for incident knee surgery and opioid use in patients with knee osteoarthritis

Y Zheng, J Zhang, Z Wang, X Liu, Y Xu, Y Fang… - Frontiers in …, 2023 - frontiersin.org
Objective To investigate whether depression and exposure to anti-depressant medication
are independent risk factors for incident knee surgery and opioid use in knee osteoarthritis …

[HTML][HTML] Budget impact of the Walk With Ease program for knee osteoarthritis

MT Kumara, RJ Cleveland, AM Kostic… - … and Cartilage Open, 2024 - Elsevier
Abstract Objective Walk With Ease (WWE) is an effective low-cost walking program. We
estimated the budget impact of implementing WWE in persons with knee osteoarthritis (OA) …