Modulation of cellular processes by histone and non-histone protein acetylation
M Shvedunova, A Akhtar - Nature reviews Molecular cell biology, 2022 - nature.com
Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
[HTML][HTML] Epigenetics, DNA damage, and aging
C Soto-Palma, LJ Niedernhofer… - The Journal of …, 2022 - Am Soc Clin Investig
Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …
abundance of several types of chromatin changes. The abundance of DNA lesions …
Pathological implication of protein post-translational modifications in cancer
S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …
[PDF][PDF] A systematic review of animal models of NAFLD finds high‐fat, high‐fructose diets most closely resemble human NAFLD
YR Im, H Hunter, D de Gracia Hahn, A Duret… - …, 2021 - Wiley Online Library
Background and Aims Animal models of human disease are a key component of
translational hepatology research, yet there is no consensus on which model is optimal for …
translational hepatology research, yet there is no consensus on which model is optimal for …
Protein post-translational modifications in the regulation of cancer hallmarks
Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function
regulation, play important roles in regulating a variety of cellular physiological and …
regulation, play important roles in regulating a variety of cellular physiological and …
[HTML][HTML] Acetate revisited: A key biomolecule at the nexus of metabolism, epigenetics and oncogenesis—Part 1: Acetyl-CoA, acetogenesis and acyl-CoA short-chain …
JR Moffett, N Puthillathu, R Vengilote… - Frontiers in …, 2020 - frontiersin.org
Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …
derived from the diet or from fermentation in the colon, has been implicated in a range of …
Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer
MORC family CW-type zinc finger 2 (MORC2) is an oncogenic chromatin-remodeling
enzyme with an emerging role in DNA repair. Here, we report a novel function for MORC2 in …
enzyme with an emerging role in DNA repair. Here, we report a novel function for MORC2 in …
Histone methylation and the DNA damage response
Preserving genome function and stability are paramount for ensuring cellular homeostasis,
an imbalance in which can promote diseases including cancer. In the presence of DNA …
an imbalance in which can promote diseases including cancer. In the presence of DNA …
[HTML][HTML] Investigating crosstalk between H3K27 acetylation and H3K4 trimethylation in CRISPR/dCas-based epigenome editing and gene activation
W Zhao, Y Xu, Y Wang, D Gao, J King, Y Xu… - Scientific reports, 2021 - nature.com
Epigenome editing methods enable the precise manipulation of epigenetic modifications,
such as histone posttranscriptional modifications (PTMs), for uncovering their biological …
such as histone posttranscriptional modifications (PTMs), for uncovering their biological …
Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair
F Gong, T Clouaire, M Aguirrebengoa, G Legube… - Journal of Cell …, 2017 - rupress.org
Upon DNA damage, histone modifications are dynamically reshaped to accommodate DNA
damage signaling and repair within chromatin. In this study, we report the identification of …
damage signaling and repair within chromatin. In this study, we report the identification of …