Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …

Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

Background and Aims Animal models of human disease are a key component of
translational hepatology research, yet there is no consensus on which model is optimal for …

Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function
regulation, play important roles in regulating a variety of cellular physiological and …

Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …

MORC family CW-type zinc finger 2 (MORC2) is an oncogenic chromatin-remodeling
enzyme with an emerging role in DNA repair. Here, we report a novel function for MORC2 in …

Preserving genome function and stability are paramount for ensuring cellular homeostasis,
an imbalance in which can promote diseases including cancer. In the presence of DNA …

Epigenome editing methods enable the precise manipulation of epigenetic modifications,
such as histone posttranscriptional modifications (PTMs), for uncovering their biological …

Upon DNA damage, histone modifications are dynamically reshaped to accommodate DNA
damage signaling and repair within chromatin. In this study, we report the identification of …