Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives

A Pawełczyk, L Zaprutko - Future Medicinal Chemistry, 2020 - Taylor & Francis
At the end of 2019, a novel virus causing severe acute respiratory syndrome to spread
globally. There are currently no effective drugs targeting SARS-CoV-2. In this study, based …

Engineered production of bioactive natural products from medicinal plants

O Fidan, J Ren, J Zhan - World Journal of Traditional Chinese …, 2022 - journals.lww.com
Plant natural products have been particularly important due to their use in food, cosmetic,
and pharmaceutical industries. In particular, Traditional Chinese Medicine provides a …

Antitussive noscapine and antiviral drug conjugates as arsenal against COVID-19: a comprehensive chemoinformatics analysis

N Kumar, A Awasthi, A Kumari, D Sood… - Journal of …, 2022 - Taylor & Francis
Coronavirus pandemic has caused a vast number of deaths worldwide. Thus creating an
urgent need to develop effective counteragents against novel coronavirus disease (COVID …

Bioactivity and in silico studies of isoquinoline and related alkaloids as promising antiviral agents: an insight

D Sharma, N Sharma, N Manchanda, SK Prasad… - Biomolecules, 2022 - mdpi.com
Viruses are widely recognized as the primary cause of infectious diseases around the world.
The ongoing global pandemic due to the emergence of SARS-CoV-2 further added fuel to …

Volatile molecules for COVID‐19: A possible pharmacological strategy?

C Colalto - Drug Development Research, 2020 - Wiley Online Library
COVID‐19 is a novel coronavirus disease with a higher incidence of bilateral pneumonia
and pleural effusion. The high pulmonary tropism and contagiousness of the virus, severe …

Developing benzylisoquinoline alkaloid-enriched opium poppy via CRISPR-directed genome editing: A review

Z Aghaali, MR Naghavi - BMC Plant Biology, 2024 - Springer
Among plant-derived secondary metabolites are benzylisoquinoline alkaloids (BIAs) that
play a vital role in medicine. The most conspicuous BIAs frequently found in opium poppy …

Lithium as a candidate treatment for COVID‐19: promises and pitfalls

RP Rajkumar - Drug Development Research, 2020 - Wiley Online Library
The pandemic of respiratory illness caused by a novel coronavirus (SARS‐nCoV‐2) is a
global health crisis. Despite numerous preliminary results, there is as yet no treatment of …

Biological and pharmacological activities of noscapine: focusing on its receptors and mechanisms

F Nourbakhsh, VR Askari - BioFactors, 2021 - Wiley Online Library
Noscapine has been mentioned as one of the effective drugs with potential therapeutic
applications. With few side effects and amazing capabilities, noscapine can be considered …

Evaluation of noscapine-licorice combination effects on cough relieving in COVID-19 outpatients: A randomized controlled trial

S Barati, F Feizabadi, H Khalaj… - Frontiers in …, 2023 - frontiersin.org
Background: As February 2023, SARS-CoV-2 is still infecting people and children
worldwide. Cough and dyspnea are annoying symptoms almost present in a large …

Synthesis and modification of noscapine derivatives as promising future anticancer agents

F Nemati, P Salehi - Bioorganic Chemistry, 2024 - Elsevier
Noscapine, a tetrahydroisoquinoline alkaloid, was first isolated from Papaver somniferum
and identified by Rabiquet in 1817. It has been used as an anti-tussive agent since the mid …