Following detection of bacteria, macrophages switch their metabolism from oxidative
respiration through the tricarboxylic acid cycle to high-rate aerobic glycolysis. This …

Bacteria have developed a wealth of strategies to avoid and resist the action of antibiotics,
one of which involves pathogens invading and forming reservoirs within host cells. Due to …

A structurally balanced social network is a social community that splits into two antagonistic
factions (typical example being a two-party political system). The process of opinion forming …

The interaction between host and pathogen decidedly shapes the outcome of an infection,
thus understanding this interaction is critical to the treatment of a pathogen-induced …

Highlights•Arginine as an energy source in the host and pathogen.•Arginine-dependent NO
production.•Modulation of arginine metabolism—strategy for immune evasion by …

Nitrogen metabolism of Mycobacterium tuberculosis (Mtb) is crucial for the survival of this
important pathogen in its primary human host cell, the macrophage, but little is known about …

Bacterial antimicrobial resistance is posed to become a major hazard to global health in the
21st century. An aggravating issue is the stalled antibiotic research pipeline, which requires …

Several major pathogens, including Mycobacterium tuberculosis, parasitize host cells and
exploit host-derived nutrients to sustain their own metabolism. Although the carbon sources …

The lifestyle of intracellular pathogens has always questioned the skill of a microbiologist in
the context of finding the permanent cure to the diseases caused by them. The best tool …

Novel approaches are required to address the looming threat of pan-resistant Gram-
negative pathogens and forestall the rise of untreatable infections. Unconventional targets …