Ancestral environmental exposures such as toxicants, abnormal nutrition or stress can
promote the epigenetic transgenerational inheritance of disease and phenotypic variation …

Stress often affects our social lives. When undergoing high-level or persistent stress,
individuals frequently retract from social interactions and become irritable and hostile …

To the Editor—Human organoids hold tremendous potential for biomedical applications 1–3
(Fig. 1a, b). These three-dimensional structures of cultured cells recapitulate important …

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and
environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) …

Parents' stressful experiences can influence an offspring's vulnerability to many pathological
conditions, including psychopathologies, and their effects may even endure for several …

Fetal development is a critical period for shaping the lifelong health of an individual.
However, the fetus is susceptible to internal and external stimuli that can lead to adverse …

Neuropsychiatric disease frequently presents with an underlying hyporeactivity or
hyperreactivity of the HPA stress axis, suggesting an exceptional vulnerability of this circuitry …

Brain plasticity is dynamically regulated across the life span, peaking during windows of
early life. Typically assessed in the physiological range of milliseconds (real time), these …

The prefrontal cortex (PFC) receives input from all other cortical regions and functions to
plan and direct motor, cognitive, affective, and social behavior across time. It has a …

Behavioural traits in mammals are influenced by environmental factors, which can interact
with the genome and modulate its activity by complex molecular interplay. Environmental …