Currently, the demand for more reliable drug screening devices has made scientists and
researchers develop novel potential approaches to offer an alternative to animal studies …

The extracellular matrix (ECM), a major component of the tumor microenvironment,
promotes local invasion to drive metastasis. Here, we describe a method to study whole …

Intratumoral heterogeneity is a negative prognostic factor for cancer and commonly
attributed to microenvironment-driven genetic mutations and/or the emergence of cancer …

Triple-negative breast cancer (TNBC) is the most aggressive and deadly subtype of breast
cancer, accounting for 30,000 cases annually in the United States. While there are several …

Background There is a critical need to better understand the mechanisms that drive local cell
invasion and metastasis to develop new therapeutics targeting metastatic disease …

To spread from a localized tumor, metastatic cancer cells must squeeze through
constrictions that cause major nuclear deformations. Since chromosome structure affects …

Cell motility under physiological and pathological conditions including malignant
progression of cancer and subsequent metastasis are founded on environmental …

Metastasis accounts for 90% of cancer-related deaths, yet the mechanisms by which cancer
cells colonize secondary organs remain poorly understood. For breast cancer patients …

Tissue microenvironments affect the functional states of cancer cells, but determining these
influences in vivo has remained a challenge. We present a quantitative high-resolution …

Three-dimensional (3D) models have led to a paradigm shift in disease modeling in vitro,
particularly for cancer. The past decade has seen a phenomenal increase in the …