Cardiovascular diseases (CVDs) contribute to a large part of worldwide mortality. Similarly,
two of the major risk factors for these diseases, aging and obesity, are also global problems …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the
majority of cell types. Here we review the sources and metabolism of ROS in this organelle …

Extracellular thiol/disulfide redox environments are highly regulated in healthy individuals.
The major thiol/disulfide redox couple in human plasma is cysteine (Cys) and its disulfide …

Chronic renal and vascular oxidative stress in association with an enhanced inflammatory
burden are determinant processes in the development and progression of diabetic …

Elevated concentrations of dietary selenium (Se) cause abnormalities and extirpation of fish
inhabiting in Se-contaminated environments. However, its effect on fish behavior and the …

This review focuses on the role of oxidative processes in atherosclerosis and the
cardiovascular diseases (CVD) that can arise as a result. Atherosclerosis represents a state …

Mitochondria possess a Ca 2+ transport system composed of separate Ca 2+ influx and
efflux pathways. Intramitochondrial Ca 2+ concentrations regulate oxidative …

Oxidative stress (OS) has been demonstrated to be involved in the pathogenesis of the two
major types of dementia: Alzheimer's disease (AD) and vascular dementia (VaD). Evidence …

The incidence of many diseases rises sharply with age. Although clearly separable, ageing
and certain age-related diseases might share common mechanisms. Cellular metabolism …