Although most cells produce two equal daughters during mitosis, some can divide
asymmetrically by segregating protein determinants into one of their two daughter cells …

The Drosophila ventral nerve cord has been a central model system for studying the
molecular genetic mechanisms that control CNS development. Studies show that the …

Metabolic reprogramming is a key feature of many cancers, but how and when it contributes
to tumorigenesis remains unclear. Here we demonstrate that metabolic reprogramming …

The p16INK4a cyclin-dependent kinase inhibitor is implicated in replicative senescence, the
state of permanent growth arrest provoked by cumulative cell divisions or as a response to …

In Chance, Development, and Aging, two leading biological gerontologists review and
evaluate all of the available data to elucidate the respective roles played by genes and …

Stem cells have the remarkable ability to give rise to both self-renewing and differentiating
daughter cells. Drosophila neural stem cells segregate cell-fate determinants from the self …

Stem cells and neuroblasts derived from mouse embryos undergo repeated asymmetric cell
divisions, generating neural lineage trees similar to those of invertebrates. In Drosophila …

Asymmetric localization is a prerequisite for inscuteable (insc) to function in coordinating
and mediating asymmetric cell divisions in Drosophila. We show here that Partner of …

Cell-fate diversity is generated in part by the unequal segregation of cell-fate determinants
during asymmetric cell divisions. In the Drosophila pupa, the pI sense organ precursor cell is …

During Drosophila embryonic CNS development, the sequential neuroblast (NB) expression
of four proteins, Hunchback (Hb), Pou-homeodomain proteins 1 and 2 (referred to …