Sickle cell trait occurs in approximately 300 million people worldwide, with the highest
prevalence of approximately 30% to 40% in sub-Saharan Africa. Long considered a benign …

Although the molecular pathways leading to the progressive deterioration of stored red
blood cells (RBC storage lesion) and the clinical relevance of storage‐induced changes …

Etavopivat is an investigational, oral, small molecule activator of erythrocyte pyruvate kinase
(PKR) in development for the treatment of sickle cell disease (SCD) and other …

2008/0184495 Al 8/2008 Brun et al. 2010/0120863 AL 5/2010 Biftu et al. 2010/0144594 A1
6/2010 Zoller et al. 2010/0216774 Al 8/2010 Bender et al. 2010/0324030 A1 12/2010 Dale …

The use of blood products for different medical purposes has increased in recent years. To
meet increasing demand, some blood centers allow volunteer donors with thalassemic trait …

summary Sickle cell trait (SCT) affects approximately 8% of the population in Martinique
(FWI) and about the same rate is found among the African Americans. In several regions of …

1. Tsen L C. The more the merrier: should anesthesiologists be present for multiple births?
Int J Obstet Anesth 2008; 17: 205–7. 2. Carvalho B, Saxena A, Butwick A, Macario A. Vaginal …

O Brasil apresenta alta prevalência de hemoglobina S, com nítidas diferenças regionais
marcadas pelos processos de miscigenação da população. A presença desta hemoglobina …

Background With the implementation of universal leucoreduction of blood components in
several industrialised countries, the problems associated with leucocyte filtration of sickle …

Background and Objectives Red blood cells (RBCs) from patients with sickle cell disease
present reduced deformability. The aim of this study was to analyse the elasticity of stored …