A vast array of αβ T cell receptors (TCRs) is generated during T cell development in the
thymus through V (D) J recombination, which involves the rearrangement of multiple V, D …

αβ T cells are critical components of the adaptive immune system and are capable of
inducing sterilizing immunity after pathogen infection and eliminating transformed tumor …

How T-cell receptor (TCR) characteristics determine subset commitment during T-cell
development is still unclear. Here, we addressed this question for innate-like T cells …

In this review, we described the structure and organization of antigen-recognizing
repertoires of B and T cells from the standpoint of modern immunology. We summarized the …

Autoimmune inflammation is characterized by tissue infiltration and expansion of antigen-
specific T cells. Although this inflammation is often limited to specific target tissues, it …

The interaction of the T-cell receptor (TCR) with a peptide in the major histocompatibility
complex (pMHC) plays a central role in the adaptive immunity of higher chordates. Due to …

Determinants of memory T cell longevity following severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated …

Immune cell–mediated inflammation is important in normal tissue regeneration but can be
pathologic in diabetic wounds. Limited literature exists on the role of CD4+ T cells in normal …

Mycobacterium tuberculosis (Mtb) remains a major threat worldwide, although only a fraction
of infected individuals develops tuberculosis (TB). TB susceptibility is shaped by multiple …

We systematically examine the receptor repertoire in T cell subsets in young, adult, and
LCMV-infected mice. Somatic recombination generates diversity, resulting in the limited …