Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …

The role of right ventricular (RV) fibrosis in pulmonary hypertension (PH) remains a subject
of ongoing discussion. Alterations of the collagen network of the extracellular matrix may …

Pulmonary arterial hypertension (PAH) is an obstructive pulmonary vasculopathy,
characterized by excess proliferation, apoptosis resistance, inflammation, fibrosis, and …

Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to
RV failure. While RV fibrosis reflects changes in the function of resident RV fibroblasts …

Joint biomechanical functions rely on the integrity of cartilage extracellular matrix.
Understanding the molecular activities that govern cartilage matrix assembly is critical for …

Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial
hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV …

Knowledge pertaining to the involvement of transforming growth factor β (TGF-β) and bone
morphogenetic protein (BMP) signaling in pulmonary arterial hypertension (PAH) is …

Right ventricular failure predicts adverse outcome in patients with pulmonary hypertension
(PH), and in subjects with left ventricular heart failure and is associated with interstitial …

Sustained hypertension causes structural, functional, and neurohumoral abnormalities in the
heart, a disease commonly termed hypertensive heart disease (HHD). Modern concepts of …

Pulmonary arterial hypertension (PAH) is defined foremost by a distinct pulmonary vascular
pathophenotype that occurs as a result of dysregulated vascular cell proliferation, intimal …