Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

Release of hemoglobin into plasma is a physiological phenomenon associated with
intravascular hemolysis. In plasma, stable haptoglobin‐hemoglobin complexes are formed …

Autoinhibition is being widely used in nature to repress otherwise constitutive protein
activities and is typically regulated by extrinsic factors. Here we show that autoinhibition can …

Hemoglobin A (HbA), the oxygen delivery system in humans, comprises two α and two β
subunits. Free α-hemoglobin (αHb) is unstable, and its precipitation contributes to the …

Prolyl isomerizations are intrinsically slow processes. They determine the rates of many
protein folding reactions and control regulatory events in folded proteins. Prolyl isomerases …

Erythrocyte precursors produce abundant α-and β-globin proteins, which assemble with
each other to form hemoglobin A (HbA), the major blood oxygen carrier. αHb-stabilizing …

The synthesis of haemoglobin A (HbA) is exquisitely coordinated during erythrocyte
development to prevent damaging effects from individual α-and β-subunits,. The α …

Multisubunit complexes containing molecular chaperones regulate protein production,
stability, and degradation in virtually every cell type. We are beginning to recognize how …

Hemoglobin biosynthesis in erythrocyte precursors involves several steps. The correct ratios
and concentrations of normal alpha (α) and beta (β) globin proteins must be expressed; …

This work employs electrospray mass spectrometry (ESI-MS) and UV− vis spectroscopy for
monitoring the mechanism of acid-induced hemoglobin (Hb) denaturation. The protein for …