Mounting evidence suggests that acute and chronic stress, especially the stress-induced
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …

The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …

Metastasis—the disseminated growth of tumours in distant organs—underlies cancer
mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and …

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) and tau deposition in brain. It
has emerged that Aβ toxicity is tau dependent, although mechanistically this link remains …

A pivotal role for excitotoxicity in neurodegenerative diseases is gaining increasingly more
acceptance, but the underlying mechanisms through which it participates in …

Amyloid-β peptide is elevated in the brains of patients with Alzheimer disease and is
believed to be causative in the disease process. Amyloid-β reduces glutamatergic …

PDZ domains are protein-interaction domains that are often found in multi-domain
scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large …

Objective A severe but treatable form of immune‐mediated encephalitis is associated with
antibodies in serum and cerebrospinal fluid (CSF) against the GluN1 subunit of the N …

The number and subunit composition of synaptic N-methyl-d-aspartate receptors (NMDARs)
are not static, but change in a cell-and synapse-specific manner during development and in …

Long-term potentiation and long-term depression are processes that have been widely
studied to understand the molecular basis of information storage in the brain. Glutamate …