The neuroscience community has witnessed a tremendous expansion of glia research. Glial
cells are now on center stage with leading roles in the development, maturation, and …

Recent studies have demonstrated that neuroplasticity, such as synaptic plasticity and
neurogenesis, exists throughout the normal lifespan but declines with age and is …

It was recently suggested that supplying the brain with new neurons could counteract
Alzheimer's disease (AD). This provocative idea requires further testing in experimental …

Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …

Neurogenesis is significantly reduced in Alzheimer's disease (AD) and is a potential
therapeutic target. Contrary to humans, a zebrafish can regenerate its diseased brain, and …

Late-onset Alzheimer's disease (LOAD) is significantly more frequent in Hispanics than in
non-Hispanic Whites. Ancestry may explain these differences across ethnic groups. To this …

Alzheimer's disease (AD) is the most common dementia worldwide and is characterized by
the presence of senile plaques by amyloid-beta (Aβ) and neurofibrillary tangles of …

Induced pluripotent stem cell-derived organoids offer an unprecedented access to complex
human tissues that recapitulate features of architecture, composition and function of in vivo …

Genetic variants in ABCA7, an Alzheimer's disease (AD)-associated gene, elevate AD risk,
yet its functional relevance to the etiology is unclear. We generated a CRISPR-Cas9 …

Alzheimer's disease cannot be cured as of yet. Our current understanding on the causes of
Alzheimer's disease is limited. To develop treatments, experimental models that represent a …