Merged magnetic resonance and light sheet microscopy of the whole mouse brain
We have developed workflows to align 3D magnetic resonance histology (MRH) of the
mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen …
mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen …
[HTML][HTML] The use, standardization, and interpretation of brain imaging data in clinical trials of neurodegenerative disorders
AJ Schwarz - Neurotherapeutics, 2021 - Elsevier
Imaging biomarkers play a wide-ranging role in clinical trials for neurological disorders. This
includes selecting the appropriate trial participants, establishing target engagement and …
includes selecting the appropriate trial participants, establishing target engagement and …
The role of neurofilament light in genetic frontotemporal lobar degeneration
H Zetterberg, C Teunissen, J van Swieten… - Brain …, 2023 - academic.oup.com
Genetic frontotemporal lobar degeneration caused by autosomal dominant gene mutations
provides an opportunity for targeted drug development in a highly complex and clinically …
provides an opportunity for targeted drug development in a highly complex and clinically …
Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer's disease
N Spotorno, O Strandberg, E Stomrud, S Janelidze… - Brain, 2024 - academic.oup.com
There is increased interest in developing markers reflecting microstructural changes that
could serve as outcome measures in clinical trials. This is especially important after …
could serve as outcome measures in clinical trials. This is especially important after …
Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults
Noninvasive biomarkers of early neuronal injury may help identify cognitively normal
individuals at risk of developing Alzheimer's disease (AD). A recent diffusion-weighted …
individuals at risk of developing Alzheimer's disease (AD). A recent diffusion-weighted …
Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer's disease
The basis of visual short-term memory (VSTM) impairments in preclinical Alzheimer's
disease (AD) remains unclear. Research suggests that eye movements may serve as …
disease (AD) remains unclear. Research suggests that eye movements may serve as …
MRAβ: A multimodal MRI‐derived amyloid‐β biomarker for Alzheimer's disease
Y Zhang, X Li, Y Ji, H Ding, X Suo, X He… - Human Brain …, 2023 - Wiley Online Library
Abstract Florbetapir 18F (AV45), a highly sensitive and specific positron emission
tomographic (PET) molecular biomarker binding to the amyloid‐β of Alzheimer's disease …
tomographic (PET) molecular biomarker binding to the amyloid‐β of Alzheimer's disease …
Higher cortical thickness/volume in Alzheimer's-related regions: Protective factor or risk factor?
Some evidence suggests a biphasic pattern of changes in cortical thickness wherein higher,
rather than lower, thickness is associated with very early Alzheimer's disease (AD) …
rather than lower, thickness is associated with very early Alzheimer's disease (AD) …
Exercise training-related changes in cortical gray matter diffusivity and cognitive function in mild cognitive impairment and healthy older adults
Individuals with Mild Cognitive Impairment (MCI) are at an elevated risk of dementia and
exhibit deficits in cognition and cortical gray matter (GM) volume, thickness, and …
exhibit deficits in cognition and cortical gray matter (GM) volume, thickness, and …
[HTML][HTML] Visual short-term memory impairments in presymptomatic familial Alzheimer's disease: A longitudinal observational study
Visual short-term memory (VSTM) deficits including VSTM binding have been associated
with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet …
with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet …