During the metastatic progression, invading cells might achieve degradation and
subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature …

Transforming growth factor β (TGF-β), a pluripotent cytokine and a multifunctional growth
factor has a crucial role in varied biological mechanisms like invasion, migration, epithelial …

Background: Recent studies highlight the carcinogenesis role of SHC-adaptor protein 1
(SHC1) in cancer initiation, development, and progression. However, its aberrant …

The genetic alterations contributing to migration proficiency, a phenotypic hallmark of
metastatic cells required for colonizing distant organs, remain poorly defined. Here, we used …

Members of the human Zyxin family are LIM domain-containing proteins that perform critical
cellular functions and are indispensable for cellular integrity. Despite their importance, not …

Paxillin is one of the most important adapters in integrin-mediated adhesions that performs
numerous crucial functions relying on its dynamic interactions. Its structural behavior serves …

DEAD-box helicase 27 (DDX27) was previously identified as an important mediator during
carcinogenesis, while its role in gastric cancer (GC) is not yet fully elucidated. Here, we …

Background Compared to minimally invasive brain metastases (MI BrM), highly invasive (HI)
lesions form abundant contacts with cells in the peritumoral brain parenchyma and are …

Background Lipoma preferred partner (LPP) polymorphisms are related to immune
diseases, but the role of LPP gene in the pathogenesis of allergic rhinitis (AR) is unclear …

Cancer cell invasion and metastasis rely on invadopodia, important extensions of the
cytoskeleton that initiate degradation of the basement membrane that holds a cell in place …