Mitochondrial gene editing
WK Shoop, SR Bacman, JD Barrera-Paez… - Nature Reviews …, 2023 - nature.com
Mutations in mitochondrial DNA (mtDNA) are responsible for several severe diseases that
have no available cures. The multicopy nature of the mitochondrial genome means that …
have no available cures. The multicopy nature of the mitochondrial genome means that …
Mitochondrial cardiomyopathy: molecular epidemiology, diagnosis, models, and therapeutic management
J Yang, S Chen, F Duan, X Wang, X Zhang, B Lian… - Cells, 2022 - mdpi.com
Mitochondrial cardiomyopathy (MCM) is characterized by abnormal heart-muscle structure
and function, caused by mutations in the nuclear genome or mitochondrial DNA. The …
and function, caused by mutations in the nuclear genome or mitochondrial DNA. The …
Mitochondrial cardiomyopathy: a fertile field for research
E Braunwald - 2023 - academic.oup.com
During the 1960s, our research group at the National Heart Institute (now the NHLBI)
focused on two seemingly different areas—the pathophysiology in patients with hypertrophic …
focused on two seemingly different areas—the pathophysiology in patients with hypertrophic …
[PDF][PDF] Mitochondrial Cardiomyopathy: Molecular Epidemiology, Diagnosis, Models, and Therapeutic Management. Cells 2022, 11, 3511
J Yang, S Chen, F Duan, X Wang, X Zhang, B Lian… - 2022 - pdfs.semanticscholar.org
Mitochondrial cardiomyopathy (MCM) is characterized by abnormal heart-muscle structure
and function, caused by mutations in the nuclear genome or mitochondrial DNA. The …
and function, caused by mutations in the nuclear genome or mitochondrial DNA. The …
Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart
L Wei, S Xia, Y Li, Y Qi, Y Wang, D Zhang, Y Hua… - Frontiers in …, 2022 - frontiersin.org
Human induced pluripotent stem cells (hIPSC) have been used to produce almost all types
of human cells currently, which makes them into several potential applications with …
of human cells currently, which makes them into several potential applications with …
Synthesizing Clinical, Genetic, Cellular, and Pathway Insights to Understand a Familial Case of Ebstein's Anomaly and Left Ventricular Noncompaction
SK Thareja - 2022 - search.proquest.com
Congenital heart defects (CHDs) are cardiogenic malformations present at or before birth
and account for a high burden of neonatal morbidity and mortality. While traditional …
and account for a high burden of neonatal morbidity and mortality. While traditional …
How can we use stem cell-derived cardiomyocytes to understand the involvement of energetic metabolism in alterations of cardiac function?
S Rebs, K Streckfuss-Bömeke - Frontiers in Molecular Medicine, 2023 - frontiersin.org
Mutations in the mitochondrial-DNA or mitochondria related nuclear-encoded-DNA lead to
various multisystemic disorders collectively termed mitochondrial diseases. One in three …
various multisystemic disorders collectively termed mitochondrial diseases. One in three …