Exercise suppresses neuroinflammation for alleviating Alzheimer's disease

M Wang, H Zhang, J Liang, J Huang… - Journal of …, 2023 - Springer
Alzheimer's disease (AD) is a chronic neurodegenerative disease, with the characteristics of
neurofibrillary tangle (NFT) and senile plaque (SP) formation. Although great progresses …

Alzheimer's disease pathogenesis: Role of autophagy and mitophagy focusing in microglia

M Eshraghi, A Adlimoghaddam… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …

Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases

X Zhang, Z Wang, Y Zheng, Q Yu… - International …, 2023 - spandidos-publications.com
The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …

[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes

D Dutta, J Liu, H Xiong - International journal of physiology …, 2022 - ncbi.nlm.nih.gov
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …

Hearing loss and cognitive impairment: epidemiology, common pathophysiological findings, and treatment considerations

A Bisogno, A Scarpa, S Di Girolamo, P De Luca… - Life, 2021 - mdpi.com
In recent years, there has been increasing research interest in the correlation between
hearing impairment and cognitive decline, two conditions that have demonstrated a strong …

NLRP1 Inflammasome activation in the hippocampal formation in Alzheimer's disease: Correlation with neuropathological changes and unbiasedly estimated …

E Španić, L Langer Horvat, K Ilić, PR Hof, G Šimić - Cells, 2022 - mdpi.com
Neuroinflammation is one of the core pathological features of Alzheimer's disease (AD) as
both amyloid β (Aβ) and tau monomers and oligomers can trigger the long-term pro …

Current progress on neuroprotection induced by Artemisia, Ginseng, Astragalus, and Ginkgo traditional Chinese medicines for the therapy of Alzheimer's disease

Q Li, L Rubin, M Silva, S Li, C Yang… - Oxidative Medicine …, 2022 - Wiley Online Library
Aging is associated with the occurrence of diverse degenerative changes in various tissues
and organs and with an increased incidence of neurological disorders, especially …

Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome

P Guo, M Zeng, S Wang, B Cao, M Liu, Y Zhang, J Jia… - Molecules, 2022 - mdpi.com
(1) Alzheimer's disease (AD) is a neurodegenerative disorder, and it is now widely accepted
that neuroinflammation plays a key role in its pathogenesis. Eriodictyol (Eri) and …

Chemical modulation of gasdermin-mediated pyroptosis and therapeutic potential

CB Ryder, HC Kondolf, ME O'Keefe, B Zhou… - Journal of molecular …, 2022 - Elsevier
Pyroptosis, a lytic form of programmed cell death, both stimulates effective immune
responses and causes tissue damage. Gasdermin (GSDM) proteins are a family of pore …

Targeting microglia in Alzheimer's disease: From molecular mechanisms to potential therapeutic targets for small molecules

ZM Althafar - Molecules, 2022 - mdpi.com
Alzheimer's disease (AD) is a common, progressive, and devastating neurodegenerative
disorder that mainly affects the elderly. Microglial dysregulation, amyloid-beta (Aβ) plaques …