Berberine as a potential anticancer agent: A comprehensive review

A Rauf, T Abu-Izneid, AA Khalil, M Imran, ZA Shah… - Molecules, 2021 - mdpi.com
Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial
amount of research has been conducted to date to establish the anticancer potential of BBR …

Neuroprotective properties of berberine: Molecular mechanisms and clinical implications

E Tian, G Sharma, C Dai - Antioxidants, 2023 - mdpi.com
Berberine (BBR), an isoquinoline alkaloid natural product, is isolated primarily from Coptis
chinensis and other Berberis plants. BBR possesses various bioactivities, including …

[HTML][HTML] Protective effects of naringin on glucocorticoid-induced osteoporosis through regulating the PI3K/Akt/mTOR signaling pathway

X Ge, G Zhou - American Journal of Translational Research, 2021 - ncbi.nlm.nih.gov
Objective: To investigate the protective effects of Naringin on glucocorticoid-induced
osteoporosis (GIOP) through the PI3K/AKT/mTOR signaling pathway in vivo and in vitro …

Berberine exerts anti-tumor activity in diffuse large B-cell lymphoma by modulating c-myc/CD47 axis

S Ren, Y Cai, S Hu, J Liu, Y Zhao, M Ding… - Biochemical …, 2021 - Elsevier
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin
lymphoma (NHL) with high clinical heterogeneity and poor prognosis. Immune escape …

[HTML][HTML] Natural Compounds for Preventing Age-Related Diseases and Cancers

MR Ki, S Youn, DH Kim, SP Pack - International Journal of Molecular …, 2024 - mdpi.com
Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental
elements. As time progresses, the human body experiences degenerative changes in major …

[HTML][HTML] A bird's eye view on a therapeutically 'wonder molecule': Berberine

P Patel - Phytomedicine Plus, 2021 - Elsevier
Berberine is a quaternary ammonium salt and naturally occurring benzylisoquinoline
alkaloid, present in numerous medicinal herbs' roots and stem bark as an active constituent …

Metformin-enhances resilience via hormesis

EJ Calabrese, E Agathokleous, R Kapoor… - Ageing Research …, 2021 - Elsevier
The present paper demonstrates that metformin (MF) induced a broad spectrum of hormetic
biphasic dose responses in a wide range of experimental studies, affecting multiple organ …

Hormesis Effect of Berberine against Klebsiella pneumoniae Is Mediated by Up-Regulation of the Efflux Pump KmrA

Y Li, H Wen, X Ge - Journal of Natural Products, 2021 - ACS Publications
Berberine (BBR) is an effective drug for human intestinal inflammation by preventing
intestinal adhesion of bacterial pathogens, while its antibacterial activity is ineffective …

Phytochemicals as Novel Therapeutics for Triple‐Negative Breast Cancer: A Comprehensive Review of Current Knowledge

ZA Bhutta, KC Choi - Phytotherapy Research, 2024 - Wiley Online Library
Triple‐negative breast cancer is a characteristic subtype of breast cancer that lacks the
estrogen receptor, human epidermal growth factor receptor 2, and progesterone receptor …

A specific super-enhancer actuated by berberine regulates EGFR-mediated RAS–RAF1–MEK1/2–ERK1/2 pathway to induce nasopharyngeal carcinoma autophagy

Y Wu, Q Jia, Q Tang, L Chen, H Deng, Y He… - Cellular & Molecular …, 2024 - Springer
Nasopharyngeal carcinoma (NPC), primarily found in the southern region of China, is a
malignant tumor known for its highly metastatic characteristics. The high mortality rates …