The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …

Bronchiectasis is conventionally defined as irreversible dilatation of the bronchial tree.
Bronchiectasis unrelated to cystic fibrosis is an increasingly appreciated cause of chronic …

There is increasing awareness of bronchiectasis in children and adolescents, a chronic
pulmonary disorder associated with poor quality of life for the child/adolescent and their …

Although survival of individuals with cystic fibrosis (CF) has been continuously improving for
the past 40 years, respiratory failure secondary to recurrent pulmonary infections remains …

This European Respiratory Society statement provides a comprehensive overview on
protracted bacterial bronchitis (PBB) in children. A task force of experts, consisting of …

The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however,
little is known about its relationship to early disease progression. To better understand the …

Cough is the single most common reason for primary care physician visits and, when
chronic, a frequent indication for specialist referrals. In children, a chronic cough (> 4 weeks) …

Background Invasive methods requiring general anaesthesia are needed to sample the lung
microbiota in young children who do not expectorate. This poses substantial challenges to …

Bronchiectasis is increasing in prevalence worldwide, yet current treatments available are
limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the …

Background Protracted bacterial bronchitis (PBB) and bronchiectasis are distinct diagnostic
entities that share common clinical and laboratory features. It is postulated, but remains …