Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …

We summarize recent advances in application of MOFs as therapeutic agents, drug carriers,
imaging agents and biosensors in cancer biomedicine. A holistic perspective is adopted to …

Gendicine (recombinant human p53 adenovirus), developed by Shenzhen SiBiono
GeneTech Co. Ltd., was approved in 2003 by the China Food and Drug Administration …

Purpose The research of long non-coding RNAs (lncRNAs) has become a new passion with
the discovery of abundant new lncRNAs and extensive investigation of their roles in various …

The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …

The ultimate purpose of current cancer research is to develop a comprehensive treatment for
cancer. Recent studies have shown an increased interest in investigating the capacity of …

Cancer remained a major cause of death providing diversified challenges in terms of
treatment including non-specific toxicity, chemoresistance and relapse. Nanotechnology …

Three decades of promise have culminated in the development of gene therapies that can
be applied to a broad range of human diseases. After a brief history, we provide an overview …

Aims Mechanical forces surrounding solid tumors are pervasive in the tumor
microenvironment (TME) and abnormally altered as solid tumors progress. Although it has …

Piezo-type mechanosensitive ion channel component 1 (Piezo1) is a mechanosensitive ion
channel protein that is evolutionarily conserved and multifunctional. It plays an important …