Stem cell fate in cancer growth, progression and therapy resistance
NK Lytle, AG Barber, T Reya - Nature Reviews Cancer, 2018 - nature.com
Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …
growth, and how these signals can be targeted, effective control of this disease remains a …
The glucocorticoid receptor: pivot of depression and of antidepressant treatment?
Hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis and increased levels of
glucocorticoid hormones in patients with depression have mostly been ascribed to impaired …
glucocorticoid hormones in patients with depression have mostly been ascribed to impaired …
Gene size matters: an analysis of gene length in the human genome
While it is expected for gene length to be associated with factors such as intron number and
evolutionary conservation, we are yet to understand the connections between gene length …
evolutionary conservation, we are yet to understand the connections between gene length …
Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis
C Anacker, A Cattaneo, A Luoni, K Musaelyan… - …, 2013 - nature.com
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular
mechanisms underlying their effects are unknown. We, therefore, investigated the molecular …
mechanisms underlying their effects are unknown. We, therefore, investigated the molecular …
Silica nanorattle–doxorubicin-anchored mesenchymal stem cells for tumor-tropic therapy
Low targeting efficiency is one of the biggest limitations for nanoparticulate drug delivery
system-based cancer therapy. In this study, an efficient approach for tumor-targeted drug …
system-based cancer therapy. In this study, an efficient approach for tumor-targeted drug …
Evolution of the human life cycle
Social mammals have three basic stages of postnatal development: infant, juvenile, and
adult. Some species also have a brief female post‐reproductive stage. The human life cycle …
adult. Some species also have a brief female post‐reproductive stage. The human life cycle …
Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness
H Yin, J Wang, H Li, Y Yu, X Wang, L Lu, C Lv… - Nature …, 2021 - nature.com
Abstract Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs
but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report …
but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report …
Zebrafish—As an integrative model for twenty‐first century toxicity testing
NS Sipes, S Padilla, TB Knudsen - Birth Defects Research Part …, 2011 - Wiley Online Library
The zebrafish embryo is a useful small model for investigating vertebrate development
because of its transparency, low cost, transgenic and morpholino capabilities, conservation …
because of its transparency, low cost, transgenic and morpholino capabilities, conservation …
Role of ATP‐binding cassette transporters in brain lipid transport and neurological disease
WS Kim, CS Weickert, B Garner - Journal of neurochemistry, 2008 - Wiley Online Library
The brain is lipid‐rich compared to other organs and although previous studies have
highlighted the importance of ATP‐binding cassette (ABC) transporters in the regulation of …
highlighted the importance of ATP‐binding cassette (ABC) transporters in the regulation of …
ABC transport proteins in cardiovascular disease—A brief summary
T Schumacher, RA Benndorf - Molecules, 2017 - mdpi.com
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters may play an important
role in the pathogenesis of atherosclerotic vascular diseases due to their involvement in …
role in the pathogenesis of atherosclerotic vascular diseases due to their involvement in …