Stem cell fate in cancer growth, progression and therapy resistance

NK Lytle, AG Barber, T Reya - Nature Reviews Cancer, 2018 - nature.com
Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

The glucocorticoid receptor: pivot of depression and of antidepressant treatment?

C Anacker, PA Zunszain, LA Carvalho… - …, 2011 - Elsevier
Hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis and increased levels of
glucocorticoid hormones in patients with depression have mostly been ascribed to impaired …

Gene size matters: an analysis of gene length in the human genome

I Lopes, G Altab, P Raina, JOP De Magalhães - Frontiers in genetics, 2021 - frontiersin.org
While it is expected for gene length to be associated with factors such as intron number and
evolutionary conservation, we are yet to understand the connections between gene length …

Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis

C Anacker, A Cattaneo, A Luoni, K Musaelyan… - …, 2013 - nature.com
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular
mechanisms underlying their effects are unknown. We, therefore, investigated the molecular …

Silica nanorattle–doxorubicin-anchored mesenchymal stem cells for tumor-tropic therapy

L Li, Y Guan, H Liu, N Hao, T Liu, X Meng, C Fu, Y Li… - ACS …, 2011 - ACS Publications
Low targeting efficiency is one of the biggest limitations for nanoparticulate drug delivery
system-based cancer therapy. In this study, an efficient approach for tumor-targeted drug …

Evolution of the human life cycle

B Bogin, BH Smith - American Journal of Human Biology: The …, 1996 - Wiley Online Library
Social mammals have three basic stages of postnatal development: infant, juvenile, and
adult. Some species also have a brief female post‐reproductive stage. The human life cycle …

Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness

H Yin, J Wang, H Li, Y Yu, X Wang, L Lu, C Lv… - Nature …, 2021 - nature.com
Abstract Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs
but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report …

Zebrafish—As an integrative model for twenty‐first century toxicity testing

NS Sipes, S Padilla, TB Knudsen - Birth Defects Research Part …, 2011 - Wiley Online Library
The zebrafish embryo is a useful small model for investigating vertebrate development
because of its transparency, low cost, transgenic and morpholino capabilities, conservation …

Role of ATP‐binding cassette transporters in brain lipid transport and neurological disease

WS Kim, CS Weickert, B Garner - Journal of neurochemistry, 2008 - Wiley Online Library
The brain is lipid‐rich compared to other organs and although previous studies have
highlighted the importance of ATP‐binding cassette (ABC) transporters in the regulation of …

ABC transport proteins in cardiovascular disease—A brief summary

T Schumacher, RA Benndorf - Molecules, 2017 - mdpi.com
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters may play an important
role in the pathogenesis of atherosclerotic vascular diseases due to their involvement in …