The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

Direct conversion of nonneural cells to functional neurons holds great promise for
neurological disease modeling and regenerative medicine. We previously reported rapid …

Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal
differentiation when expressed in neural progenitor cells. The mechanisms by which …

The spinal cord integrates and relays somatosensory input, leading to complex motor
responses. Research over the past couple of decades has identified transcription factor …

The spinal cord of vertebrate animals is comprised of intrinsic circuits that are capable of
sensing the environment and generating complex motor behaviors. There are two major …

Mutations in the human and mouse PTF1A/Ptf1a genes result in permanent diabetes
mellitus and cerebellar agenesis. We show that Ptf1a is present in precursors to GABAergic …

Proneural genes are crucial regulators of neurogenesis and subtype specification in many
areas of the nervous system; however, their function in dopaminergic neuron development is …

The bHLH (basic helix-loop-helix) transcription factor Mash1 is best known for its role in the
regulation of neurogenesis. However, Mash1 is also expressed in oligodendrocyte …

Sensory information from the periphery is integrated and transduced by excitatory and
inhibitory interneurons in the dorsal spinal cord. Recent studies have identified a number of …