Alzheimer's and Parkinson's disease therapies in the clinic

P Chopade, N Chopade, Z Zhao… - Bioengineering & …, 2023 - Wiley Online Library
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent
neurodegenerative diseases, affecting millions and costing billions each year in the United …

Mitochondrial dysfunction in Parkinson's disease–a key disease hallmark with therapeutic potential

MT Henrich, WH Oertel, DJ Surmeier… - Molecular …, 2023 - Springer
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

[HTML][HTML] Recent developments in the treatment of Parkinson's Disease

TB Stoker, RA Barker - F1000Research, 2020 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a common neurodegenerative disease typified by a movement
disorder consisting of bradykinesia, rest tremor, rigidity, and postural instability. Treatment …

Brain-derived neurotropic factor in neurodegenerative disorders

AM Ibrahim, L Chauhan, A Bhardwaj, A Sharma… - Biomedicines, 2022 - mdpi.com
Globally, neurodegenerative diseases cause a significant degree of disability and distress.
Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role …

Anti-Parkinsonian therapy: strategies for crossing the blood–brain barrier and nano-biological effects of nanomaterials

G Cheng, Y Liu, R Ma, G Cheng, Y Guan, X Chen… - Nano-micro letters, 2022 - Springer
Abstract Parkinson's disease (PD), a neurodegenerative disease that shows a high
incidence in older individuals, is becoming increasingly prevalent. Unfortunately, there is no …

Development, wiring and function of dopamine neuron subtypes

O Garritsen, EY van Battum, LM Grossouw… - Nature Reviews …, 2023 - nature.com
The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …

Probiotics for Parkinson's disease

P Gazerani - International journal of molecular sciences, 2019 - mdpi.com
Parkinson's disease (PD) is a complex neurological disorder classically characterized by
impairments in motor system function associated with loss of dopaminergic neurons in the …

[HTML][HTML] Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson's disease

E Kip, LC Parr-Brownlie - Ageing Research Reviews, 2022 - Elsevier
Parkinson's disease (PD) is the second most common age-associated neurodegenerative
disorder and is characterised by progressive loss of dopamine neurons in the substantia …

Resveratrol derivatives as potential treatments for Alzheimer's and Parkinson's disease

BD Arbo, C André-Miral, RG Nasre-Nasser… - Frontiers in aging …, 2020 - frontiersin.org
Neurodegenerative diseases are characterized by the progressive loss of neurons in
different regions of the nervous system. Alzheimer's disease (AD) and Parkinson's disease …

The role of vitamins in neurodegenerative disease: An update

SN Rai, P Singh, HWM Steinbusch, E Vamanu… - Biomedicines, 2021 - mdpi.com
Acquiring the recommended daily allowance of vitamins is crucial for maintaining
homeostatic balance in humans and other animals. A deficiency in or dysregulation of …