Intrahepatic cholangiocarcinoma (iCCA) has over the last 10‐20 years become the focus of
increasing concern, largely due to its rising incidence and high mortality rates worldwide …

Tumour microenvironment is a complex, multicellular functional compartment that,
particularly when assembled as an abundant desmoplastic reaction, may profoundly affect …

This study investigated the exosomal circular RNAs (CircRNAs) produced by tumor-
associated macrophages and delivered into the microenvironment of cholangiocarcinoma …

Intrahepatic cholangiocarcinoma (ICC), a type of bile duct cancer, has a high mortality rate.
Gut microbiota, bile acid (BA) metabolism, and cytokines have not been characterized in …

Tumor‐associated macrophages (TAMs) play a pivotal role in tumor growth in human
malignancies. Published studies have analyzed the relationship between TAM infiltration …

Tumor‐associated macrophages (TAMs) in the tumor microenvironment have been
associated with enhanced tumor progression. In this study, we investigated the role and …

Cholangiocarcinoma (CCA) is an aggressive tumor with a poor prognosis due to its late
clinical presentation and the lack of effective non-surgical therapies. Unfortunately, most of …

Cholangiocarcinoma (CCA) is a dismal disease which often is diagnosed at a late stage
where the tumor is locally advanced, metastatic, and, as a result, is associated with low …

Cholangiocarcinoma (CCA) is an aggressive and multifactorial malignancy of the biliary
tract. The carcinogenesis of CCA is associated with genomic and epigenetic abnormalities …

The family of vascular endothelial growth factors (VEGFs) includes 5 members (VEGF-A to-
D, and placenta growth factor), which regulate several critical biological processes. VEGF-A …