Ovarian cancer is the main cause of death among all reproductive cancers in females. In
2018, ovarian cancer was the seventh most common cancer of women entire the world. A …

Autotaxin (ATX) is a member of the nucleotide pyrophosphatase/phosphodiesterase family
of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. It possesses …

Maternal diabetes adversely affects preimplantation embryo development and pregnancy
outcomes. The objective of this study was to determine whether diabetes has an impact at …

The mitochondria-associated membrane (MAM) has emerged as an endoplasmic reticulum
(ER) signaling hub that accommodates ER chaperones, including the lectin calnexin. At the …

Lysophosphatidic acid (LPA) is a signaling lipid that binds to six known lysophosphatidic
acid receptors (LPARs), named LPA 1-LPA 6. These receptors initiate signaling cascades …

Autotaxin (ATX) is a member of the ectonucleotide pyrophosphate/phosphodiesterase
(ENPP) family; it is encoded by the ENPP2 gene. ATX is a secreted glycoprotein and …

BACKGROUND Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are two
prominent signaling lysophospholipids (LPs) exerting their functions through a group of G …

Hypoxia and signaling via hypoxia-inducible factor-1 (HIF-1) is a key feature of solid tumors
and is related to tumor progression as well as treatment failure. Although it is generally …

Background & Aims: We recently identified lysophosphatidic acid (LPA) as a potent
antiapoptotic agent for the intestinal epithelium. The objective of the present study was to …

Developing therapeutics that induce apoptosis in cancer cells has become an increasingly
attractive approach for the past 30 years. The discovery of tumor necrosis factor (TNF) …