AAV analysis by sedimentation velocity analytical ultracentrifugation: beyond empty and full capsids

AE Yarawsky, V Zai-Rose, HM Cunningham… - European Biophysics …, 2023 - Springer
The recent surge of therapeutic interest in recombinant adeno-associated viral (AAV) vectors
for targeted DNA delivery has brought analytical ultracentrifugation (AUC) into the spotlight …

Characterization and quantification of adeno-associated virus capsid-loading states by multi-wavelength analytical ultracentrifugation with UltraScan

A Henrickson, X Ding, AG Seal, Z Qu, L Tomlinson… - …, 2023 - Taylor & Francis
Aim: We present multi-wavelength (MW) analytical ultracentrifugation (AUC) methods
offering superior accuracy for adeno-associated virus characterization and quantification …

Methods for the Design and Analysis of Analytical Ultracentrifugation Experiments

B Demeler - Current Protocols, 2024 - Wiley Online Library
Analytical ultracentrifugation experiments play an integral role in the solution‐phase
characterization of biological macromolecules and their interactions. This unit discusses the …

Proceedings of the 25th analytical ultracentrifugation workshops and symposium

B Demeler, R Gilbert, TR Patel - European Biophysics Journal, 2023 - Springer
Abstract The 25th International Analytical Ultracentrifugation (AUC) Workshops and
Symposium (AUC2022) took place at the University of Lethbridge in Lethbridge, Canada, in …

Optimizing high-throughput viral vector characterization with density gradient equilibrium analytical ultracentrifugation

SM Sternisha, AD Wilson, E Bouda… - European Biophysics …, 2023 - Springer
Viral vector-based gene therapies and vaccines require accurate characterization of capsid
species. The current gold standard for assessing capsid loading of adeno-associated virus …

Improving Gene Therapy Analysis With Multi-Wavelength Analytical Ultracentrifugation Methods

A Henrickson - 2023 - search.proquest.com
Over the past few years, research into gene therapies has dramatically increased, with
thousands of drug candidates in clinical trials. However, only a few are available on the …

[PDF][PDF] カプシドタンパク質の化学量論比に着目したアデノ随

大西一幸 - 2024 - ir.library.osaka-u.ac.jp
Osaka University Knowledge Archive : OUKA Page 1 Title カプシドタンパク質の化学量論比に
着目したアデノ随 伴ウイルスベクターの特性解析と応用 Author(s) 大西, 一幸 Citation 大阪大学 …