Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1

Y Jang, W Kim, P Leblanc, CH Kim… - Experimental & Molecular …, 2021 - nature.com
Abstract Until recently, Nurr1 (NR4A2) was known as an orphan nuclear receptor without a
canonical ligand-binding domain, featuring instead a narrow and tight cavity for small …

Roles of EP receptors in the regulation of fluid balance and blood pressure

L Wang, Y Wu, Z Jia, J Yu, S Huang - Frontiers in Endocrinology, 2022 - frontiersin.org
Prostaglandin E2 (PGE2) is an important prostanoid expressing throughout the kidney and
cardiovascular system. Despite the diverse effects on fluid metabolism and blood pressure …

Induction of p53-Dependent Apoptosis by Prostaglandin A2

SB Lee, S Lee, JY Park, SY Lee, HS Kim - Biomolecules, 2020 - mdpi.com
Prostaglandin (PG) A2, one of cyclopentenone PGs, is known to induce activation of
apoptosis in various cancer cells. Although PGA2 has been reported to cause activation of …

Cross-Conjugated Cyclopentenone Prostaglandins. Recent Advances

VV Loza, AM Gimazetdinov, MS Miftakhov - Russian Journal of Organic …, 2018 - Springer
The review covers the literature on the total synthesis of cross-conjugated cyclopentenone
prostaglandins (PGs), published from 2000 until present. In view of the specific features …

Кросс-сопряженные циклопентеноновые простагландины. Последние достижения

ВВ Лоза, АМ Гимазетдинов… - Журнал органической …, 2018 - elibrary.ru
Обзор охватывает литературные данные по полному синтезу кросс-сопряженных
циклопентеноновых простагландинов с 2000 г. С учётом специфических отличий …

PGA2-induced HO-1 attenuates G2M arrest by modulating GADD45α expression

YJ Choe, KW Ko, H Lee, SY Lee, BC Kim… - Molecular & Cellular …, 2015 - Springer
Abstract Prostaglandin (PG) A 2, a cyclopentenone PG, arrested the growth of U2OS cells in
the G 2 M phase. While inducing G 2 M arrest, PGA 2 increased the expression of heme …

[HTML][HTML] NSAIDs Effect on Bone Healing

RM Zeeshan - 2024 - intechopen.com
The extensive use of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of
severe pain associated with bone fractures raises concerns regarding their impact on …

13,14-Dehydro-16-phenoxy-PGB1 Ethyl Esters: Synthesis and Some Properties

GA Shavaleeva, NA Ivanova, AK Utemisova… - Russian Journal of …, 2023 - Springer
13,14-Dehydro-16-phenoxy-PGB1 Ethyl Esters: Synthesis and Some Properties | Russian
Journal of General Chemistry Skip to main content SpringerLink Account Menu Find a journal …

Hepatoprotective action of prostaglandin A2 analogs under CCl4‐induced liver injury in vitro

AI Hubich, AY Bondar, TU Kastsiuk… - Hepatology …, 2007 - Wiley Online Library
Aim: The cytoprotective effects of six novel synthetic prostaglandin A2 analogs against
carbon tetrachloride (CCl4) as a toxic agent were studied with isolated rat liver hepatocytes …

Structural features of prostanoid analogues involved in hepatocytes protection against CCl4-induced injury

MV Sholukh, AI Hubich, FS Pashkovsky… - Prostaglandins & Other …, 2010 - Elsevier
The ability of natural prostaglandins (PGs) and synthetic prostanoids of B, H and E1-types to
prevent CCl4-induced liver injury in vitro was examined. Seven analogs of PGB, 3 …