Regenerative therapy for the Cornea

A Kumar, H Yun, ML Funderburgh, Y Du - Progress in retinal and eye …, 2022 - Elsevier
The cornea is the outmost layer of the eye, unique in its transparency and strength. The
cornea not only transmits the light essential for vision, also refracts light, giving focus to …

Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes

CY Liu, AC Arteaga, SE Fung, MS Cortina… - The ocular …, 2021 - Elsevier
Neurotrophic keratopathy is a degenerative disease in which damage to the corneal nerves
leads to corneal hypoesthesia. Injuries to neurotrophic corneas are notoriously difficult to …

Direct versus indirect corneal neurotization for the treatment of neurotrophic keratopathy: a multicenter prospective comparative study

P Fogagnolo, G Giannaccare, F Bolognesi… - American Journal of …, 2020 - Elsevier
Purpose To analyze the comparative safety and efficacy of two techniques of corneal
neurotization (CN)(direct corneal neurotization [DCN] vs indirect corneal neurotization [ICN]) …

Corneal stroma regeneration: Preclinical studies

JLA Del Barrio, F Arnalich-Montiel… - Experimental Eye …, 2021 - Elsevier
Corneal grafting is one of the most common and successful forms of human tissue
transplantation in the world, but the need for corneal grafting is growing and availability of …

Eight months follow-up of corneal nerves and sensitivity after treatment with cenegermin for neurotrophic keratopathy

E Pedrotti, E Bonacci, C Chierego… - Orphanet Journal of …, 2022 - Springer
Abstract Backgroud Cenegermin (Oxervate, Dompè Farmaceutici, Milan, IT), a recombinant
human NGF, is a potentially healing new drug for neurotrophic keratopathy (NK), a rare but …

Efficacy of treatments for neurotrophic keratopathy: a systematic review and meta-analysis

S Roumeau, F Dutheil, V Sapin, JS Baker… - Graefe's Archive for …, 2022 - Springer
Purpose Management of NK can be difficult, involving a range of treatments with variable
efficacy. We conducted a systematic review and meta-analysis to evaluate the efficacy of …

Outcomes of corneal neurotisation using processed nerve allografts: a multicentre case series

AR Sweeney, M Wang, CL Weller, C Burkat… - British Journal of …, 2022 - bjo.bmj.com
Background Corneal neurotisation is a rapidly evolving procedure treating neurotrophic
keratopathy. The variety of surgical techniques used and corresponding outcomes after …

Minimally invasive corneal neurotization provides sensory function, protects against recurrent ulceration, and improves visual acuity

JH Woo, SC Daeschler, K Mireskandari… - American Journal of …, 2022 - Elsevier
PURPOSE To measure sensory recovery after minimally invasive corneal neurotization, and
to identify and quantify the extent to which patient and technical factors influence sensory …

Neurotrophic keratopathy in pediatric patients

C Scelfo, IS Mantagos - Seminars in Ophthalmology, 2021 - Taylor & Francis
Purpose: This review provides an overview of the causes and treatment of neurotrophic
keratopathy in the pediatric population. Methods: A thorough review of the current literature …

Corneal neurotization for postherpetic neurotrophic keratopathy: initial experience and clinical outcomes

JS Kim, L Rafailov, IM Leyngold - Ophthalmic Plastic & …, 2021 - journals.lww.com
Purpose: To assess early outcomes of corneal neurotization for postherpetic neurotrophic
keratopathy (NK). Methods: Retrospective analysis of patients who underwent corneal …